Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMDQH9A)

• Drug Name: ADL-5859 Drug Info
• Synonyms: PF-04856880
• Cross-matching ID:
  PubChem CID: 46931003
  CAS Number: CAS 850173-95-4
  TTD Drug ID: D0W9ZT

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Steroid biosynthesis	2.38	0.00e+0	19/20 (95%)	MSMO1;CYP51A1;NSDHL;...
Terpenoid backbone biosynthesis	2.23	0.00e+0	18/22 (81.82%)	HMGCS1;IDI1;ACAT2;...
Synthesis and degradation of ketone bodies	1.90	1.60e-2	9/10 (90%)	HMGCS1;ACAT2
Cell cycle	1.78	4.62e-2	110/124 (88.71%)	SFN;SMC1A;E2F2;...
Fc gamma R-mediated phagocytosis	-1.76	4.94e-2	79/97 (81.44%)	PRKCD;ARPC5;ACTR3;...
N-Glycan biosynthesis	-1.86	3.03e-2	38/50 (76%)	MGAT4C;MAN1B1;STT3A;...
Tuberculosis	-1.88	3.12e-2	159/180 (88.33%)	MAPK10;IRAK4;ITGAX;...
Type I diabetes mellitus	-1.95	9.75e-3	38/43 (88.37%)	LTA;FAS;HLA-E;...
Allograft rejection	-2.00	0.00e+0	32/38 (84.21%)	FAS;HLA-E;HLA-DQB1;...
Graft-versus-host disease	-2.12	0.00e+0	32/42 (76.19%)	FAS;HLA-E;HLA-DQB1;...
Protein export	-2.17	0.00e+0	17/23 (73.91%)	SRP9;SEC61B;SEC62;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	1.25uM - 10uM	24H	Hide ▲

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	1.25uM - 10uM	24H	Hide ▲