Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMDQVY4)

Drug Name
ABT-724 Drug Info
Synonyms 2-[4-(2-Pyridyl)piperazin-1-ylmethyl]-1H-benzimidazole maleate
Cross-matching ID
PubChem CID
5025739
ChEBI ID
CHEMBL440687
CAS Number
CAS 70006-24-5
TTD Drug ID
D03TNA

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
DNA replication 2.14 0.00e+0 34/36 (94.44%) PCNA;POLD2;POLE2;...
IL-17 signaling pathway 2.12 0.00e+0 84/94 (89.36%) LCN2;CXCL5;CCL20;...
Mismatch repair 1.95 6.85e-3 22/23 (95.65%) PCNA;POLD2;MLH1;...
TNF signaling pathway 1.94 7.70e-3 103/112 (91.96%) CXCL5;CCL20;CXCL6;...
Steroid biosynthesis 1.93 6.16e-3 19/20 (95%) EBP;TM7SF2;NSDHL;...
Viral protein interaction with cytokine and cytokine re... 1.89 1.03e-2 84/100 (84%) CXCL5;CCL20;CXCL8;...
Biosynthesis of unsaturated fatty acids 1.75 4.99e-2 21/27 (77.78%) TECR;FADS2;SCD;...
Mineral absorption 1.75 4.36e-2 48/60 (80%) MT1X;MT1E;HMOX1;...
Renin-angiotensin system -1.81 2.43e-2 20/23 (86.96%) ENPEP;ACE2;MME;...
Protein digestion and absorption -1.83 1.62e-2 78/103 (75.73%) MEP1B;COL5A2;COL8A2;...
ECM-receptor interaction -1.84 1.94e-2 80/88 (90.91%) ITGA2B;COL4A1;ITGB4;...
Notch signaling pathway -1.84 3.88e-2 49/59 (83.05%) NOTCH4;JAG2;KAT2A;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.03uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.04uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.04uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.04uM - 10uM 24H