General Information of Drug (ID: DMDTA36)

Drug Name
A-252444.0 Drug Info
Synonyms A-155918; A-205804; A-241548
Cross-matching ID
TTD Drug ID
D09GGO

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name NES FDR q-val Tag % Leading Edge Genes
DNA replication 2.34 0.00e+0 34/36 (94.44%) PCNA;MCM5;SSBP1;...
Ribosome 2.21 0.00e+0 113/158 (71.52%) MRPL20;RPS4Y1;MRPS16;...
Mismatch repair 1.99 0.00e+0 22/23 (95.65%) PCNA;SSBP1;POLD2;...
RNA transport 1.97 4.09e-3 128/186 (68.82%) EIF2S3;NUP155;CLNS1A;...
Cholesterol metabolism 1.95 3.27e-3 44/50 (88%) CD36;LPL;PLTP;...
One carbon pool by folate 1.93 2.72e-3 15/20 (75%) AMT;MTR;TYMS;...
Ribosome biogenesis in eukaryotes 1.93 2.33e-3 52/108 (48.15%) NHP2;RRP7A;POP4;...
Fructose and mannose metabolism 1.89 4.09e-3 30/33 (90.91%) SORD;GMDS;MPI;...
Nucleotide excision repair 1.80 9.08e-3 40/47 (85.11%) PCNA;POLD2;CCNH;...
Galactose metabolism 1.80 9.80e-3 26/31 (83.87%) GALE;PFKM;B4GALT1;...
Cell cycle 1.79 9.66e-3 110/124 (88.71%) CHEK2;PCNA;TFDP2;...
Aminoacyl-tRNA biosynthesis 1.79 8.85e-3 15/66 (22.73%) CARS2;LARS2;QRSL1;...
Proteasome 1.78 8.17e-3 44/46 (95.65%) PSMA7;POMP;PSMB4;...
Spliceosome 1.77 8.75e-3 101/150 (67.33%) HSPA8;LSM5;TCERG1;...
PPAR signaling pathway 1.73 1.53e-2 66/74 (89.19%) CD36;LPL;PLTP;...
Arginine and proline metabolism 1.70 2.71e-2 39/50 (78%) AOC1;CKM;ODC1;...
RNA degradation 1.65 3.60e-2 53/79 (67.09%) ENO3;LSM5;MTREX;...
Folate biosynthesis 1.61 4.77e-2 23/26 (88.46%) GCH1;QDPR;CBR1;...
Epithelial cell signaling in Helicobacter pylori infect... -1.68 4.39e-2 62/70 (88.57%) PTPN11;ADAM17;HBEGF;...
Mitophagy -1.70 4.07e-2 56/68 (82.35%) TBK1;OPTN;ATG5;...
Adherens junction -1.70 4.28e-2 63/71 (88.73%) ACP1;SSX2IP;PTPN1;...
Lysosome -1.71 4.34e-2 115/128 (89.84%) ATP6V0A4;GGA2;CLN3;...
Axon guidance -1.74 3.07e-2 151/182 (82.97%) PLXNB3;SEMA4A;SRGAP3;...
Regulation of actin cytoskeleton -1.74 3.14e-2 185/218 (84.86%) FGF5;APC;MAP2K2;...
Rheumatoid arthritis -1.76 2.77e-2 78/93 (83.87%) ITGAL;ATP6V0A1;CD80;...
Pancreatic cancer -1.76 3.07e-2 75/76 (98.68%) RALBP1;MAPK10;E2F3;...
Melanoma -1.78 2.30e-2 68/72 (94.44%) FGF1;EGF;PDGFRA;...
Synaptic vesicle cycle -1.79 2.47e-2 63/78 (80.77%) ATP6V0A1;NAPA;SLC17A6;...
VEGF signaling pathway -1.83 2.11e-2 50/59 (84.75%) CDC42;PXN;PPP3CB;...
mTOR signaling pathway -1.87 1.38e-2 114/154 (74.03%) RPS6KA2;CLIP1;LPIN1;...
Proteoglycans in cancer -1.89 1.44e-2 172/205 (83.9%) TWIST1;PTPN11;HOXD10;...
Ras signaling pathway -1.92 7.68e-3 201/232 (86.64%) EFNA3;PDGFC;PTPN11;...
Collecting duct acid secretion -1.96 5.76e-3 22/27 (81.48%) ATP6V0A1;ATP6V0A4;ATP6V1F;...
Renal cell carcinoma -1.98 1.15e-2 68/69 (98.55%) TGFB2;CUL2;RBX1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 1.11uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 1.11uM - 10uM 24H