Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMDUWBF)

• Drug Name: JNJ-17203212 Drug Info
• Synonyms: JNJ-17203212; 821768-06-3; JNJ 17203212; UNII-71JE0C439X; CHEMBL254778; 71JE0C439X; 4-[3-(trifluoromethyl)pyridin-2-yl]-N-[5-(trifluoromethyl)pyridin-2-yl]piperazine-1-carboxamide; 4-(3-trifluoromethyl-pyridin-2-yl)-piperazine-1-carboxylic acid (5-trifluoromethyl-pyridin-2-yl)-amide; JFRYYGVYCWYIDQ-UHFFFAOYSA-N; 4-(3-(trifluoromethyl)pyridin-2-yl)-N-(5-(trifluoromethyl)pyridin-2-yl)piperazine-1-carboxamide; JNJ17203212; SCHEMBL138342; GTPL4228; CTK5E9468; C17H15F6N5O; DTXSID50462856; AOB2189; SYN5009; MolPort-006-822-716
• Cross-matching ID:
  PubChem CID: 11339118
  ChEBI ID: CHEMBL254778
  CAS Number: CAS 821768-06-3
  TTD Drug ID: D0DY4E

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Glycine, serine and threonine metabolism	2.00	1.03e-2	31/40 (77.5%)	GLDC;PGAM1;ALAS2;...
Mineral absorption	1.96	5.14e-3	48/60 (80%)	MT1X;MT1H;MT1G;...
Adherens junction	1.92	1.37e-2	63/71 (88.73%)	SORBS1;ACTN1;TGFBR2;...
Arginine and proline metabolism	1.81	4.37e-2	39/50 (78%)	CKB;ARG2;AOC1;...
Signaling pathways regulating pluripotency of stem cell...	1.77	4.11e-2	110/143 (76.92%)	BMP4;STAT3;ID4;...
Thyroid hormone signaling pathway	1.76	4.80e-2	112/121 (92.56%)	BMP4;NOTCH2;PLN;...
Homologous recombination	-1.80	4.52e-2	35/41 (85.37%)	RAD50;BRCC3;BRCA1;...
Ovarian steroidogenesis	-1.83	4.84e-2	41/51 (80.39%)	ADCY2;PLA2G4A;CYP1A1;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	1.11uM - 10uM	24H	Hide ▲

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	1.11uM - 10uM	24H	Hide ▲