Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMDWZGJ)

• Drug Name: 5-hydroxy-L-tryptophan Drug Info
• Synonyms: 5-hydroxytryptophan
• Cross-matching ID:
  PubChem CID: 439280
  ChEBI ID: CHEMBL350221
  CAS Number: CAS 4350-09-8
  TTD Drug ID: D09BNS
  VARIDT Drug ID: DR01071

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Oxidative phosphorylation	2.14	0.00e+0	93/133 (69.92%)	ATP5MC2;CYC1;NDUFB4;...
Central carbon metabolism in cancer	-1.71	4.78e-2	67/70 (95.71%)	HIF1A;HK1;FGFR3;...
Cytokine-cytokine receptor interaction	-1.75	4.84e-2	246/295 (83.39%)	MSTN;CCL25;CCR10;...
Allograft rejection	-1.78	3.28e-2	32/38 (84.21%)	HLA-DPA1;HLA-DRB1;HLA-DMB;...
Antigen processing and presentation	-1.85	6.56e-3	60/78 (76.92%)	IFNG;NFYC;HLA-DQB1;...
Viral protein interaction with cytokine and cytokine re...	-1.87	8.20e-3	84/100 (84%)	CCL25;CCR10;CXCL13;...
IL-17 signaling pathway	-1.87	1.09e-2	84/94 (89.36%)	IFNG;CXCL6;MAPK9;...
Hematopoietic cell lineage	-1.96	0.00e+0	90/99 (90.91%)	EPOR;CD22;CD14;...
Protein processing in endoplasmic reticulum	-1.98	0.00e+0	127/171 (74.27%)	DERL2;SEC61G;EDEM3;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Fibroblast

Nasopharyngeal carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
FIBRNPC	CVCL_UK07	Homo sapiens	10uM	6H, 24H	Hide ▲