Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMDYS0L)

Drug Name
AG 112 Drug Info
Synonyms tyrphostin A48; tyrphostin AG 112; AG-112; AG112
Cross-matching ID
PubChem CID
5328804
ChEBI ID
CHEMBL76589
CAS Number
CAS 122520-87-0
TTD Drug ID
D02KVB

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Oxidative phosphorylation 2.24 0.00e+0 93/133 (69.92%) COX7B;NDUFB2;ATP5MG;...
Ribosome 2.04 0.00e+0 113/158 (71.52%) MRPL15;RPL26L1;MRPL17;...
Parkinson disease 2.01 2.46e-3 176/249 (70.68%) GPR37;CYCS;PSMA6;...
Prion disease 2.00 5.54e-3 209/273 (76.56%) HSPA8;CYCS;PSMA6;...
Proteasome 1.96 4.43e-3 44/46 (95.65%) PSMA6;PSMA1;PSMC6;...
DNA replication 1.95 3.69e-3 34/36 (94.44%) POLE2;POLE3;RPA3;...
Drug metabolism 1.93 4.22e-3 78/151 (51.66%) UGT2B28;UGT2B17;UGT2B15;...
Legionellosis 1.81 1.11e-2 51/57 (89.47%) CXCL2;HSPA8;CYCS;...
Oocyte meiosis 1.80 1.07e-2 90/129 (69.77%) CCNB1;CDK1;CALML3;...
Amyotrophic lateral sclerosis 1.74 1.92e-2 267/364 (73.35%) CYCS;PSMA6;COX7B;...
Huntington disease 1.68 3.69e-2 233/306 (76.14%) CYCS;PSMA6;COX7B;...
RNA degradation 1.67 3.63e-2 53/79 (67.09%) LSM5;PAN2;TENT4A;...
RNA polymerase 1.66 3.35e-2 23/31 (74.19%) POLR2D;POLR2L;POLR3B;...
Retinol metabolism 1.65 3.53e-2 41/68 (60.29%) UGT2B28;UGT2B17;UGT2B15;...
Bile secretion 1.63 3.99e-2 68/90 (75.56%) CA2;UGT2B28;UGT2B17;...
Caffeine metabolism 1.63 3.74e-2 5/6 (83.33%) NAT1;NAT2;CYP1A2;...
RNA transport 1.61 4.69e-2 128/186 (68.82%) EEF1A2;TACC3;RAN;...
Alzheimer disease 1.61 4.59e-2 279/369 (75.61%) GAPDH;LPL;CYCS;...
Thiamine metabolism 1.60 4.78e-2 12/15 (80%) AK4;AK1
Thermogenesis 1.59 4.65e-2 173/232 (74.57%) COX7B;NDUFB2;ATP5MG;...
Ribosome biogenesis in eukaryotes 1.58 4.96e-2 52/108 (48.15%) RAN;RPP40;POP5;...
Mucin type O-glycan biosynthesis -1.71 3.64e-2 20/36 (55.56%) GALNT3;GALNT2;GALNT7;...
MicroRNAs in cancer -1.71 3.90e-2 146/310 (47.1%) APC2;PDGFB;EGFR;...
Glioma -1.74 3.42e-2 67/75 (89.33%) MAPK3;PDGFRB;IGF1R;...
Hepatocellular carcinoma -1.75 3.17e-2 135/168 (80.36%) FZD2;MAPK3;IGF1R;...
ErbB signaling pathway -1.76 3.11e-2 79/85 (92.94%) MAP2K2;PAK4;JUN;...
Non-small cell lung cancer -1.76 3.30e-2 70/72 (97.22%) RARB;KIF5C;MAPK3;...
Transcriptional misregulation in cancer -1.77 3.38e-2 158/192 (82.29%) NCOR1;TCF3;CEBPB;...
Basal cell carcinoma -1.77 3.01e-2 41/63 (65.08%) TCF7L1;DVL2;BMP2;...
Melanoma -1.78 3.44e-2 68/72 (94.44%) MAPK3;PDGFRB;IGF1R;...
Pancreatic cancer -1.78 3.59e-2 75/76 (98.68%) MAPK3;TGFB1;PIK3CB;...
Prostate cancer -1.80 3.30e-2 93/97 (95.88%) FGFR1;TCF7L1;CREB3L2;...
Small cell lung cancer -1.81 4.12e-2 90/92 (97.83%) ITGA2;LAMA4;RARB;...
Ferroptosis -1.84 3.38e-2 36/41 (87.8%) ACSL4;FTL;STEAP3;...
Gastric cancer -1.86 4.44e-2 122/149 (81.88%) APC2;EGFR;TGFB2;...
Chronic myeloid leukemia -2.00 1.27e-2 72/76 (94.74%) MECOM;MAPK3;TGFB1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-673 CVCL_0080 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 6H, 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CL-34 CVCL_1123 Homo sapiens 10uM 6H
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 6H, 24H
LoVo CVCL_0399 Homo sapiens 10uM 6H
MDST8 CVCL_1400 Homo sapiens 10uM 6H
NCI-H508 CVCL_1561 Homo sapiens 10uM 6H
SNU-1040 CVCL_5001 Homo sapiens 10uM 6H
SNU-C4 CVCL_5008 Homo sapiens 10uM 6H
SNU-C5 CVCL_5009 Homo sapiens 10uM 6H
SW480 CVCL_0546 Homo sapiens 10uM 6H
SW620 CVCL_0547 Homo sapiens 10uM 6H
SW948 CVCL_0550 Homo sapiens 10uM 6H
Colorectal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCT 116 CVCL_0291 Homo sapiens 10uM 6H
HT115 CVCL_1294 Homo sapiens 10uM 6H
RKO CVCL_0504 Homo sapiens 10uM 6H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 10uM 6H
SNG-M CVCL_1707 Homo sapiens 10uM 6H
Endometrial carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
JHUEM-2 CVCL_1327 Homo sapiens 10uM 6H
Fibroblast
Nasopharyngeal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
FIBRNPC CVCL_UK07 Homo sapiens 10uM 6H, 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
DV-90 CVCL_1184 Homo sapiens 10uM 6H
SK-LU-1 CVCL_0624 Homo sapiens 10uM 6H
Lung adenosquamous carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H596 CVCL_1571 Homo sapiens 10uM 6H
Lung large cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COR-L23 CVCL_1133 Homo sapiens 10uM 6H
T3M-10 CVCL_1729 Homo sapiens 10uM 6H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC15 CVCL_1253 Homo sapiens 10uM 6H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1299 CVCL_0060 Homo sapiens 10uM 6H
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
NCI-H2073 CVCL_1523 Homo sapiens 10uM 6H
Small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1694 CVCL_1495 Homo sapiens 10uM 6H
NCI-H1836 CVCL_1502 Homo sapiens 10uM 6H
Lymph node
Diffuse large B-cell lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
WSU-DLCL2 CVCL_1787 Homo sapiens 10uM 6H
Ovary
Ovarian carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
EFO-27 CVCL_1194 Homo sapiens 10uM 6H
OV7 CVCL_1623 Homo sapiens 10uM 6H
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
RMG-I CVCL_1663 Homo sapiens 10uM 6H
Ovarian mucinous cystadenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COV644 CVCL_2011 Homo sapiens 10uM 6H
RMUG-S CVCL_1666 Homo sapiens 10uM 6H
Ovarian undifferentiated carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
TYK-nu CVCL_1774 Homo sapiens 10uM 6H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 10uM 6H
Acute myeloid leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NOMO-1 CVCL_1609 Homo sapiens 10uM 6H
PL-21 CVCL_2161 Homo sapiens 10uM 6H
SKM-1 CVCL_0010 Homo sapiens 10uM 6H
Pleural effusion
Histiocytic lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-937 CVCL_0007 Homo sapiens 10uM 6H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 6H, 24H
SK-MEL-1 CVCL_0523 Homo sapiens 10uM 6H
SK-MEL-28 CVCL_0526 Homo sapiens 10uM 6H
Stomach
Gastric adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
AGS CVCL_0139 Homo sapiens 10uM 6H