General Information of Drug (ID: DMDZIV5)

Drug Name
spiradoline Drug Info
Synonyms U62066; U-62066; U 62066
Cross-matching ID
PubChem CID
55652
CAS Number
CAS 87151-85-7
TTD Drug ID
D0HQ0E

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name NES FDR q-val Tag % Leading Edge Genes
PPAR signaling pathway 2.19 0.00e+0 66/74 (89.19%) SCD5;FABP7;ADIPOQ;...
Dilated cardiomyopathy 2.18 0.00e+0 86/96 (89.58%) GNAS;TNNC1;MYL2;...
Fat digestion and absorption 2.14 0.00e+0 35/43 (81.4%) PLA2G2A;PLPP3;APOB;...
Hypertrophic cardiomyopathy 2.03 5.10e-3 81/90 (90%) TNNC1;MYL2;ACTB;...
Cardiac muscle contraction 1.97 4.08e-3 64/87 (73.56%) TNNC1;MYL2;TPM3;...
Fatty acid degradation 1.84 1.19e-2 40/43 (93.02%) ADH1B;ACADM;ADH1C;...
Nitrogen metabolism 1.84 1.02e-2 16/17 (94.12%) CA4;CA2;GLUL;...
Adrenergic signaling in cardiomyocytes 1.78 2.68e-2 130/150 (86.67%) GNAS;TNNC1;PPP1R1A;...
Retinol metabolism 1.76 2.61e-2 41/68 (60.29%) ALDH1A2;ADH1B;ALDH1A1;...
Histidine metabolism 1.76 2.35e-2 16/22 (72.73%) HNMT;ALDH3A2;ALDH2;...
Pancreatic secretion 1.72 3.53e-2 87/102 (85.29%) PLA2G2A;GNAS;PLCB1;...
Glycerolipid metabolism 1.71 3.91e-2 44/61 (72.13%) MGLL;LPL;PLPP3;...
Linoleic acid metabolism 1.70 4.01e-2 21/29 (72.41%) PLA2G2A;CYP1A2;PLA2G2D;...
Arginine and proline metabolism 1.70 3.79e-2 39/50 (78%) CKM;CKB;GATM;...
Ascorbate and aldarate metabolism 1.69 4.08e-2 15/30 (50%) UGT2A3;ALDH3A2;UGDH;...
Ether lipid metabolism 1.68 3.96e-2 32/49 (65.31%) PLA2G2A;PLPP3;PLPP1;...
Vitamin digestion and absorption 1.66 4.62e-2 17/24 (70.83%) APOB;SLC5A6;APOA1;...
Tryptophan metabolism 1.66 4.59e-2 35/42 (83.33%) KYNU;CYP1B1;IDO1;...
Mineral absorption 1.65 4.51e-2 48/60 (80%) MT1X;SLC26A3;MT1G;...
Staphylococcus aureus infection -1.76 4.60e-2 72/95 (75.79%) DEFB4A;KRT19;FCGR3B;...
Mucin type O-glycan biosynthesis -1.80 3.23e-2 20/36 (55.56%) ST3GAL1;GALNT10;GCNT3;...
Graft-versus-host disease -1.85 3.39e-2 32/42 (76.19%) IL6;TNF;HLA-DQB1;...
Antigen processing and presentation -1.96 1.94e-2 60/78 (76.92%) KLRC3;CIITA;NFYA;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 1.11uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 1.11uM - 10uM 24H