Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DME15JU)

Drug Name
BW723C86 Drug Info
Synonyms BW-72386
Cross-matching ID
PubChem CID
5311036
CAS Number
CAS 160521-72-2
TTD Drug ID
D00ZCU

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Steroid biosynthesis 2.39 0.00e+0 19/20 (95%) NSDHL;MSMO1;SQLE;...
Pantothenate and CoA biosynthesis 1.95 8.06e-3 14/21 (66.67%) ALDH3A2;ALDH2;BCAT1;...
Vibrio cholerae infection 1.83 3.49e-2 44/50 (88%) ATP6V1D;PDIA4;ATP6V0E1;...
Valine, leucine and isoleucine degradation 1.82 2.82e-2 42/48 (87.5%) HMGCS1;AOX1;ALDH3A2;...
PPAR signaling pathway 1.81 2.42e-2 66/74 (89.19%) FABP4;HMGCS1;SCD;...
Terpenoid backbone biosynthesis 1.79 2.55e-2 18/22 (81.82%) IDI1;HMGCS1;FDPS;...
Cytokine-cytokine receptor interaction -1.61 4.80e-2 246/295 (83.39%) CCL13;IFNB1;OSMR;...
Proximal tubule bicarbonate reclamation -1.62 4.45e-2 21/23 (91.3%) GLS2;AQP1;ATP1B3;...
Rheumatoid arthritis -1.62 4.48e-2 78/93 (83.87%) IL1B;IL17A;IL1A;...
Bacterial invasion of epithelial cells -1.65 3.64e-2 59/77 (76.62%) PIK3CA;ITGA5;CTNNA1;...
Th17 cell differentiation -1.65 3.81e-2 95/107 (88.79%) SMAD2;IL1B;IL17A;...
PI3K-Akt signaling pathway -1.67 3.64e-2 317/354 (89.55%) IL7;IL2RG;COL9A2;...
Small cell lung cancer -1.69 3.45e-2 90/92 (97.83%) PIK3CA;RXRG;PIK3R1;...
Bile secretion -1.70 3.37e-2 68/90 (75.56%) SLC10A2;SULT2A1;AQP4;...
Asthma -1.70 3.57e-2 25/31 (80.65%) HLA-DPB1;HLA-DPA1;HLA-DMB;...
Amoebiasis -1.72 3.26e-2 99/102 (97.06%) FN1;CD1D;RELA;...
Bladder cancer -1.73 2.91e-2 40/41 (97.56%) MAPK3;MAP2K1;CCND1;...
Prostate cancer -1.73 2.94e-2 93/97 (95.88%) IGF1;PIK3CA;ETV5;...
ECM-receptor interaction -1.74 3.17e-2 80/88 (90.91%) COL9A2;SV2A;ITGA5;...
HIF-1 signaling pathway -1.78 2.22e-2 105/109 (96.33%) PDK1;ANGPT1;INSR;...
Focal adhesion -1.80 1.76e-2 180/201 (89.55%) COL9A2;IGF1;PIK3CA;...
Systemic lupus erythematosus -1.83 1.58e-2 45/135 (33.33%) HLA-DPB1;HLA-DPA1;C1QB;...
Malaria -1.84 1.62e-2 44/50 (88%) TNF;VCAM1;TGFB2;...
IL-17 signaling pathway -1.84 1.82e-2 84/94 (89.36%) IL1B;IL17A;IFNG;...
Inflammatory bowel disease -1.85 2.08e-2 58/65 (89.23%) SMAD2;IL1B;IL17A;...
TNF signaling pathway -1.85 2.02e-2 103/112 (91.96%) DNM1L;RIPK1;CXCL6;...
Viral protein interaction with cytokine and cytokine re... -1.87 2.18e-2 84/100 (84%) CCL21;CCL1;CCL18;...
Legionellosis -1.91 1.52e-2 51/57 (89.47%) TLR2;NFKB2;RAB1B;...
NF-kappa B signaling pathway -2.08 4.04e-3 90/104 (86.54%) PLAU;CXCL12;TRAF5;...
Protein digestion and absorption -2.23 0.00e+0 78/103 (75.73%) COL14A1;COL9A2;COL10A1;...
Mineral absorption -2.27 0.00e+0 48/60 (80%) ATP2B2;HEPH;ATP1B3;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H