General Information of Drug (ID: DME3WBQ)

Drug Name
DS-437 Drug Info
Synonyms DS437
Cross-matching ID
PubChem CID
91827358
TTD Drug ID
D00QZA

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name NES FDR q-val Tag % Leading Edge Genes
Osteoclast differentiation 2.20 0.00e+0 117/127 (92.13%) FOSB;JUNB;FCGR2A;...
Neutrophil extracellular trap formation 2.02 0.00e+0 101/189 (53.44%) SRC;CYBB;CLEC7A;...
Antigen processing and presentation 1.98 0.00e+0 60/78 (76.92%) HSPA8;CTSS;CTSB;...
Natural killer cell mediated cytotoxicity 1.88 1.05e-2 99/131 (75.57%) TNFSF10;ITGB2;PRKCA;...
Pancreatic cancer 1.88 1.12e-2 75/76 (98.68%) E2F2;VEGFA;TGFB1;...
Measles 1.86 1.17e-2 133/139 (95.68%) HSPA8;TNFAIP3;TLR2;...
Bladder cancer 1.79 2.80e-2 40/41 (97.56%) SRC;E2F2;DAPK1;...
NOD-like receptor signaling pathway 1.78 2.63e-2 145/181 (80.11%) CYBB;TNFAIP3;GBP2;...
TNF signaling pathway 1.76 2.80e-2 103/112 (91.96%) VCAM1;PTGS2;TNFAIP3;...
Mitophagy 1.75 2.80e-2 56/68 (82.35%) SRC;NBR1;GABARAPL1;...
Leishmaniasis 1.74 2.93e-2 67/77 (87.01%) PTGS2;CYBB;ITGB2;...
Circadian rhythm 1.74 2.69e-2 26/31 (83.87%) BHLHE41;PRKAG1;NPAS2
Hepatitis B 1.74 2.48e-2 151/162 (93.21%) SRC;E2F2;CXCL8;...
AGE-RAGE signaling pathway in diabetic complications 1.72 2.60e-2 97/100 (97%) VCAM1;CYBB;COL1A2;...
Phagosome 1.72 2.62e-2 118/152 (77.63%) CTSS;CYBB;CLEC7A;...
Toxoplasmosis 1.71 2.45e-2 103/112 (91.96%) HSPA8;LAMC2;LAMB3;...
Herpes simplex virus 1 infection 1.71 2.39e-2 165/498 (33.13%) SRC;TLR2;IFNAR2;...
Chronic myeloid leukemia 1.71 2.34e-2 72/76 (94.74%) E2F2;RUNX1;TGFB1;...
Endocytosis 1.70 2.51e-2 198/252 (78.57%) SRC;HSPA8;PIP5K1B;...
GnRH secretion 1.70 2.38e-2 60/64 (93.75%) PRKCA;KCNN4;GNAQ;...
Influenza A 1.69 2.27e-2 156/172 (90.7%) TNFSF10;TMPRSS4;CXCL8;...
Epstein-Barr virus infection 1.68 2.49e-2 189/202 (93.56%) E2F2;TNFAIP3;RELB;...
Shigellosis 1.68 2.38e-2 180/246 (73.17%) SRC;PRKCQ;CXCL8;...
Hepatitis C 1.66 2.98e-2 139/157 (88.54%) E2F2;IFNAR2;OAS1;...
Tuberculosis 1.66 3.14e-2 159/180 (88.33%) SRC;CTSS;CLEC7A;...
Platelet activation 1.65 3.18e-2 106/124 (85.48%) SRC;COL1A2;FCGR2A;...
Toll-like receptor signaling pathway 1.64 3.43e-2 94/104 (90.38%) CXCL8;TLR2;IFNAR2;...
Lipid and atherosclerosis 1.62 3.84e-2 190/215 (88.37%) SRC;HSPA8;VCAM1;...
Lysosome 1.62 3.72e-2 115/128 (89.84%) CTSS;CTSZ;CTSE;...
Necroptosis 1.61 3.65e-2 113/159 (71.07%) CYBB;TNFSF10;TNFAIP3;...
Pentose and glucuronate interconversions -1.61 4.35e-2 17/34 (50%) GUSB;UGT2B28;UGP2;...
Steroid hormone biosynthesis -1.61 4.37e-2 43/61 (70.49%) SULT2B1;HSD11B1;UGT2B28;...
Pyruvate metabolism -1.66 3.10e-2 41/47 (87.23%) ADH1C;ALDH1B1;ACAT1;...
Fat digestion and absorption -1.67 2.79e-2 35/43 (81.4%) PNLIPRP2;ABCA1;PLA2G12A;...
Caffeine metabolism -1.67 2.89e-2 5/6 (83.33%) XDH;CYP1A2;CYP2A6;...
Phenylalanine metabolism -1.68 2.76e-2 14/17 (82.35%) MAOA;ALDH3A1;GLYAT;...
Ascorbate and aldarate metabolism -1.70 2.62e-2 15/30 (50%) GUSB;UGT2B28;ALDH9A1;...
Renin-angiotensin system -1.72 2.17e-2 20/23 (86.96%) PREP;CTSG;ENPEP;...
Arginine biosynthesis -1.74 2.06e-2 17/22 (77.27%) GLS2;GLS;ASS1;...
Metabolism of xenobiotics by cytochrome P450 -1.75 2.20e-2 49/77 (63.64%) ALDH3A1;MGST2;HSD11B1;...
Fatty acid degradation -1.79 1.48e-2 40/43 (93.02%) ACAA1;CPT2;ACADSB;...
Steroid biosynthesis -1.85 7.50e-3 19/20 (95%) FDFT1;HSD17B7;LSS;...
Glycine, serine and threonine metabolism -1.85 8.58e-3 31/40 (77.5%) PSAT1;ALAS1;BHMT;...
Tyrosine metabolism -1.86 1.00e-2 30/36 (83.33%) TAT;ADH1C;TYRP1;...
Complement and coagulation cascades -1.89 6.67e-3 76/85 (89.41%) KNG1;C4BPA;CFHR4;...
PPAR signaling pathway -1.90 5.00e-3 66/74 (89.19%) ACOX2;LPL;ACAA1;...
Drug metabolism -1.94 0.00e+0 78/151 (51.66%) MAOA;IMPDH1;HPRT1;...
Mineral absorption -2.15 0.00e+0 48/60 (80%) CYBRD1;ATOX1;SLC30A1;...
Retinol metabolism -2.41 0.00e+0 41/68 (60.29%) CYP1A1;DHRS9;ALDH1A1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 1.11uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 1.11uM - 10uM 24H