Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DME5TUR)

Drug Name
LY03004 Drug Info
Synonyms Risperidone controlled release
Cross-matching ID
PubChem CID
5073
TTD Drug ID
D0X2LQ

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
DNA replication 2.35 0.00e+0 34/36 (94.44%) RPA2;RNASEH2A;PCNA;...
Mismatch repair 2.17 0.00e+0 22/23 (95.65%) RPA2;PCNA;RFC2;...
Spliceosome 2.07 3.07e-3 101/150 (67.33%) SNRPB;PUF60;TRA2B;...
Base excision repair 2.03 2.30e-3 29/33 (87.88%) PCNA;FEN1;HMGB1;...
Cell cycle 2.01 1.84e-3 110/124 (88.71%) CDC20;CCNB2;CCNA2;...
Pyrimidine metabolism 1.97 1.54e-3 40/56 (71.43%) CTPS1;TYMS;RRM2;...
Leishmaniasis 1.93 2.63e-3 67/77 (87.01%) MARCKSL1;ITGA4;NCF4;...
Oocyte meiosis 1.87 5.76e-3 90/129 (69.77%) CDC20;CCNB2;PTTG1;...
Aminoacyl-tRNA biosynthesis 1.82 1.02e-2 15/66 (22.73%) SARS2;FARSA;DARS2;...
Dilated cardiomyopathy 1.79 1.47e-2 86/96 (89.58%) TPM1;DES;PLN;...
Amoebiasis 1.71 2.76e-2 99/102 (97.06%) CXCL1;CXCL3;SERPINB6;...
RNA transport 1.70 2.76e-2 128/186 (68.82%) TACC3;NUP107;FUS;...
Progesterone-mediated oocyte maturation 1.69 2.83e-2 75/100 (75%) CCNB2;CCNA2;PLK1;...
Hematopoietic cell lineage 1.69 2.70e-2 90/99 (90.91%) ITGA4;CD14;CD44;...
Rheumatoid arthritis 1.67 2.70e-2 78/93 (83.87%) CXCL1;CXCL3;CXCL5;...
Homologous recombination 1.66 3.22e-2 35/41 (85.37%) RPA2;POLD2;RAD51B;...
Proteasome 1.64 3.90e-2 44/46 (95.65%) PSMC3;PSMC4;IFNG;...
Hypertrophic cardiomyopathy 1.61 4.96e-2 81/90 (90%) TPM1;DES;ITGA4;...
ABC transporters -1.76 4.48e-2 37/45 (82.22%) ABCB4;CFTR;ABCA5;...
Fatty acid degradation -1.79 3.65e-2 40/43 (93.02%) ALDH1B1;ACADL;ADH6;...
Selenocompound metabolism -1.83 1.88e-2 11/17 (64.71%) PAPSS2;SEPHS2;TXNRD1;...
PPAR signaling pathway -1.85 1.79e-2 66/74 (89.19%) SLC27A2;SLC27A6;ACADM;...
Ferroptosis -2.08 0.00e+0 36/41 (87.8%) PRNP;LPCAT3;ACSL5;...
Mineral absorption -2.23 0.00e+0 48/60 (80%) FTH1;MT2A;MT1M;...
×

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 6H, 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 6H, 24H
Fibroblast
Nasopharyngeal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
FIBRNPC CVCL_UK07 Homo sapiens 10uM 6H, 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HuH-7 CVCL_0336 Homo sapiens 8uM 72H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 2.22uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 6H, 24H