Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DME5Y64)

Drug Name
Tranilast Drug Info
Synonyms
tranilast; 53902-12-8; Rizaben; trans-Tranilast; Tranilastum; 70806-55-2; MK 341; N-(3,4-Dimethoxycinnamoyl)anthranilic acid; Tranilastum [INN-Latin]; Tranilast [USAN:INN:JAN]; Tranpro; UNII-HVF50SMY6E; SB-252218; MK-341; Tranilast (SB 252218); 3,4-DAA; n-(3',4'-dimethoxycinnamoyl) anthranilic acid; HVF50SMY6E; MLS000028468; CHEBI:77572; C18H17NO5; Anthranilic acid, N-(3,4-dimethoxycinnamoyl)-; NZHGWWWHIYHZNX-CSKARUKUSA-N; 2-((3-(3,4-Dimethoxyphenyl)-1-oxo-2-propenyl)amino)benzoic acid; MFCD00864787; T 0318; NU-3450; Rizaben (TN); Tranilast (JAN/USAN/INN); Rizaben, SB 252218, MK 341, Tranpro ,Tranilast; N-(3',4'-dimethoxycinnamoyl) anthranilic acid; N-(3′ -Dimethoxycinnamoyl)anthranilic Acid; 2-({(2E)-3-[3,4-bis(methyloxy)phenyl]prop-2-enoyl}amino)benzoic acid; 2-[[(E)-3-(3,4-dimethoxyphenyl)prop-2-enoyl]amino]benzoic acid; 2-[[3-(3,4-Dimethoxyphenyl)-1-oxo-2-propenyl]amino] benzoic acid; Molecule 20
Cross-matching ID
PubChem CID
5282230
ChEBI ID
CHEMBL77572
CAS Number
CAS 53902-12-8
TTD Drug ID
D0E6OC
INTEDE Drug ID
DR1628

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Mineral absorption 2.26 7.65e-3 48/60 (80%) MT1E;MT1H;MT1F;...
DNA replication 1.94 1.53e-2 34/36 (94.44%) PCNA;RPA3;POLE2;...
Pantothenate and CoA biosynthesis 1.84 1.02e-2 14/21 (66.67%) PPCS;ENPP1;AASDHPPT;...
Cell cycle 1.83 9.57e-3 110/124 (88.71%) CDC20;WEE1;PLK1;...
Mismatch repair 1.82 1.07e-2 22/23 (95.65%) PCNA;RPA3;SSBP1;...
Pyruvate metabolism 1.76 2.30e-2 41/47 (87.23%) DLD;ADH1C;ALDH2;...
Sulfur relay system 1.75 1.97e-2 5/8 (62.5%) TST;MPST;MOCS2
Arachidonic acid metabolism 1.74 2.20e-2 48/61 (78.69%) AKR1C3;PTGIS;PLA2G4A;...
Oxidative phosphorylation 1.72 2.64e-2 93/133 (69.92%) NDUFB5;ATP5ME;NDUFA6;...
Sulfur metabolism 1.70 3.21e-2 9/10 (90%) SELENBP1;TST;PAPSS2;...
Oocyte meiosis 1.68 3.55e-2 90/129 (69.77%) CDC20;PLK1;CCNB2;...
Proteasome 1.67 3.57e-2 44/46 (95.65%) PSMA3;PSMC3;PSMB8;...
Cysteine and methionine metabolism 1.65 4.00e-2 43/50 (86%) APIP;TST;ENOPH1;...
Drug metabolism 1.64 3.77e-2 78/151 (51.66%) HPRT1;MGST2;UGT2B17;...
Glyoxylate and dicarboxylate metabolism 1.64 3.62e-2 23/30 (76.67%) DLD;PCCA;GLDC;...
Parkinson disease 1.63 3.97e-2 176/249 (70.68%) PSMA3;GPR37;NDUFB5;...
Protein processing in endoplasmic reticulum -1.88 2.08e-2 127/171 (74.27%) DNAJA1;TRAM1;PREB;...
Autophagy -1.92 1.87e-2 113/169 (66.86%) DDIT4;RPS6KB2;HMGB1;...
Longevity regulating pathway -1.94 2.50e-2 90/151 (59.6%) RPS6KB2;STK11;PRKAG1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.04uM - 10uM 6H, 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 12uM - 100uM 48H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 3H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 6H, 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM - 100uM 6H, 48H
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HuH-7 CVCL_0336 Homo sapiens 10uM 72H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 6H, 24H