Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DME7VG6)

Drug Name
UK-383367 Drug Info
Synonyms
UK 383367; 348622-88-8; UK-383367; CHEMBL226630; 5-[(1R)-4-Cyclohexyl-1-[2-(hydroxyamino)-2-oxoethyl]butyl]-1,2,4-oxadiazole-3-carboxamide; (R)-5-(6-cyclohexyl-1-(hydroxyamino)-1-oxohexan-3-yl)-1,2,4-oxadiazole-3-carboxamide; ARJCBSRIPGJMAD-LLVKDONJSA-N; UK383367; 5-{(1R)-4-cyclohexyl-1-[2-(hydroxyamino)-2-oxoethyl]butyl}-1,2,4-oxadiazole-3-carboxamide; MLS006011234; SCHEMBL6430715; CTK8F1316; SYN3014; DTXSID30431303; MolPort-016-633-322; ZINC3818556; s2224; BDBM50216795; AKOS024458022; SB19579; RL03300; CS-0414
Cross-matching ID
PubChem CID
9818682
ChEBI ID
CHEMBL226630
CAS Number
CAS 348622-88-8
TTD Drug ID
D0P2TS

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Type II diabetes mellitus 1.93 2.59e-2 42/46 (91.3%) IRS2;PIK3CD;PIK3CB;...
Asthma 1.88 2.59e-2 25/31 (80.65%) PRG2;HLA-DQA1;CD40;...
N-Glycan biosynthesis 1.85 1.73e-2 38/50 (76%) DAD1;RPN1;MGAT4B;...
Regulation of lipolysis in adipocytes 1.83 1.94e-2 52/55 (94.55%) GNAS;IRS2;PRKACB;...
Steroid biosynthesis 1.77 4.15e-2 19/20 (95%) TM7SF2;DHCR7;MSMO1;...
Parkinson disease -1.76 4.39e-2 176/249 (70.68%) MAPK10;PPIF;PSMC3;...
Tyrosine metabolism -1.81 3.41e-2 30/36 (83.33%) ADH7;TPO;DDC;...
Phenylalanine metabolism -1.90 7.32e-3 14/17 (82.35%) DDC;MIF;ALDH3B1;...
Ribosome -1.91 1.46e-2 113/158 (71.52%) MRPL34;RPLP1;RPSA;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.04uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.01uM - 10uM 24H