Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMEAOZ0)

Drug Name
Cilengitide Drug Info
Synonyms
Cilengitide; 188968-51-6; EMD-121974; Cilengitide [USAN:INN]; UNII-4EDF46E4GI; EMD121974; EMD-12192; EMD 121974; 4EDF46E4GI; CHEMBL429876; 2-[(2S,5R,8S,11S)-5-benzyl-11-[3-(diaminomethylideneamino)propyl]-7-methyl-3,6,9,12,15-pentaoxo-8-propan-2-yl-1,4,7,10,13-pentazacyclopentadec-2-yl]acetic acid; Cyclo(L-arginylglycyl-L-aspartyl-D-phenylalanyl-N-methyl-L-valyl); Cyclo(L-arginylglycyl-L-alpha-aspartyl-D-phenylalanyl-N-methyl-L-valyl); Cilengitide (TFA salt)
Cross-matching ID
PubChem CID
176873
ChEBI ID
CHEMBL429876
CAS Number
CAS 188968-51-6
TTD Drug ID
D09ZXO

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Antigen processing and presentation 2.07 0.00e+0 60/78 (76.92%) CD74;HLA-DRB1;CTSS;...
DNA replication 2.03 0.00e+0 34/36 (94.44%) RPA2;RPA3;RNASEH2A;...
Asthma 2.00 0.00e+0 25/31 (80.65%) HLA-DRB1;HLA-DRA;HLA-DPA1;...
Leishmaniasis 1.96 0.00e+0 67/77 (87.01%) MARCKSL1;EEF1A2;HLA-DRB1;...
Influenza A 1.89 6.03e-3 156/172 (90.7%) HLA-DRB1;TNFSF10;HLA-DRA;...
Progesterone-mediated oocyte maturation 1.83 1.84e-2 75/100 (75%) CCNB1;ADCY3;PIK3R1;...
Protein digestion and absorption 1.78 2.58e-2 78/103 (75.73%) COL6A2;COL5A2;COL6A1;...
Herpes simplex virus 1 infection 1.77 2.39e-2 165/498 (33.13%) CD74;HLA-DRB1;BST2;...
Type I diabetes mellitus 1.75 2.90e-2 38/43 (88.37%) HLA-DRB1;HLA-DRA;HLA-DPA1;...
Toxoplasmosis 1.74 2.71e-2 103/112 (91.96%) LAMA4;HLA-DRB1;HLA-DRA;...
Allograft rejection 1.73 3.11e-2 32/38 (84.21%) HLA-DRB1;HLA-DRA;HLA-DPA1;...
Mismatch repair 1.73 2.93e-2 22/23 (95.65%) RPA2;RPA3;RFC5;...
Tuberculosis 1.72 2.78e-2 159/180 (88.33%) CD74;CD14;HLA-DRB1;...
Graft-versus-host disease 1.70 3.23e-2 32/42 (76.19%) HLA-DRB1;HLA-DRA;HLA-DPA1;...
Toll-like receptor signaling pathway 1.70 3.02e-2 94/104 (90.38%) CD14;CTSK;NFKB1;...
RIG-I-like receptor signaling pathway 1.68 3.71e-2 64/70 (91.43%) NFKB1;DDX58;IKBKE;...
Phagosome 1.67 3.84e-2 118/152 (77.63%) COLEC12;CD14;HLA-DRB1;...
Oocyte meiosis 1.66 4.19e-2 90/129 (69.77%) CCNB1;ADCY3;CCNB2;...
Alcoholism -1.70 4.40e-2 86/186 (46.24%) SLC29A2;CRH;ATF4;...
Nicotinate and nicotinamide metabolism -1.74 3.31e-2 25/35 (71.43%) NT5C;SIRT5;NT5M;...
PPAR signaling pathway -1.76 2.78e-2 66/74 (89.19%) ILK;SORBS1;APOA2;...
Fatty acid biosynthesis -1.87 7.45e-3 16/18 (88.89%) ACACA;FASN;ACSL1;...
Biosynthesis of unsaturated fatty acids -1.92 3.31e-3 21/27 (77.78%) HACD2;FADS2;HSD17B12;...
Steroid biosynthesis -2.04 0.00e+0 19/20 (95%) CYP51A1;SQLE;LSS;...
Mineral absorption -2.05 0.00e+0 48/60 (80%) CYBRD1;ATP7B;FTH1;...
×

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 0.12uM - 10uM 6H, 24H, 48H
Bone marrow
Chronic myeloid leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HAP1 CVCL_Y019 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 CDK4 (-) 1 CVCL_SI36 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 HDAC5 (-) 1 CVCL_SR11 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 ITGA4 (-) 1 CVCL_ST27 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 MAPK8 (-) 1 CVCL_SW99 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 PIK3CA (-) 1 CVCL_TD60 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 PRKACA (-) 1 CVCL_TG70 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 PRKCQ (-) CVCL_TG92 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 RELA (-) 1 CVCL_TI75 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 SRC (-) 1 CVCL_TQ36 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 TP53 (-) 1 CVCL_RJ70 Homo sapiens 0.66uM - 3.33uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 6H, 24H, 48H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 6H, 24H, 48H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.04uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.04uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.04uM - 10uM 24H