Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMEC8E2)

• Drug Name: Anle138b Drug Info
• Synonyms: Anle138b; 882697-00-9; Emrusolmin; ANLE-138b; 3-(1,3-benzodioxol-5-yl)-5-(3-bromophenyl)-1h-pyrazole; Emrusolmin [INN]; E7WRA77JET; 5-(1,3-benzodioxol-5-yl)-3-(3-bromophenyl)-1H-pyrazole; CHEMBL4748063; 3-(Benzo[d][1,3]dioxol-5-yl)-5-(3-bromophenyl)-1H-pyrazole; 1H-Pyrazole, 3-(1,3-benzodioxol-5-yl)-5-(3-bromophenyl)-; Anle 138b; UNII-E7WRA77JET; Anle 138b; Anle-138b; SCHEMBL1660250; SCHEMBL21440048; BCP32558; Anle138b, >=98% (HPLC); BDBM50553260; MFCD30146410; NSC805132; s6782; AKOS037649277; CS-6522; DB13927; NSC-805132; BS-17773; HY-101855; D80685; EN300-331610; A858288; Z2327237898; 3-(1,3-dioxaindan-5-yl)-5-(3-bromophenyl)-1H-pyrazole
• Cross-matching ID:
  PubChem CID: 44608289
  ChEBI ID: CHEMBL4748063
  TTD Drug ID: DS8V3L

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Amino sugar and nucleotide sugar metabolism	-1.82	3.63e-2	38/48 (79.17%)	GCK;MPI;CHIT1;...
Asthma	-1.87	1.51e-2	25/31 (80.65%)	CCL11;HLA-DPB1;FCER1G;...
Leishmaniasis	-1.93	1.36e-2	67/77 (87.01%)	FCGR2A;TLR2;IFNGR2;...
Steroid hormone biosynthesis	-2.06	0.00e+0	43/61 (70.49%)	COMT;CYP11B1;HSD17B2;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone

Osteosarcoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
U-2 OS	CVCL_0042	Homo sapiens	0.37uM - 10uM	24H	Hide ▲

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	0.37uM - 10uM	24H	Hide ▲