Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMEDMC0)

• Drug Name: (+)-AJ76 Drug Info
• Synonyms: AJ 76; AJ-76; 5-methoxy-1-methyl-2-(n-propylamino)tetralin; 85379-09-5; CHEMBL27441; (+)-AJ 76; CHEBI:64117; (1S,2R)-5-methoxy-1-methyl-N-propyl-1,2,3,4-tetrahydronaphthalen-2-amine; cis-(+)-5-methoxy-1-methyl-2-(propylamino)tetralin; (1S,2R)-5-methoxy-1-methyl-2-(propylamino)tetralin; 2-Naphthalenamine, 1,2,3,4-tetrahydro-5-methoxy-1-methyl-N-propyl-, (1S-cis)-; Tocris-0678; (+)-AJ76; AC1L3UEJ; a j76; Biomol-NT_000004; GTPL970; SCHEMBL276252; AJ76; BPBio1_001129; DTXSID1043889; BDBM81797; ZINC3995669; PDSP2_000777; BDBM50041959
• Cross-matching ID:
  PubChem CID: 122334
  ChEBI ID: CHEMBL64117
  CAS Number: CAS 85379-09-5
  TTD Drug ID: D0X1QW

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Oocyte meiosis	1.88	4.97e-2	90/129 (69.77%)	CCNB1;PPP3CB;CDC20;...
Regulation of actin cytoskeleton	1.74	4.97e-2	185/218 (84.86%)	MYL9;FGFR3;PDGFRA;...
Ovarian steroidogenesis	-1.74	3.65e-2	41/51 (80.39%)	CGA;ADCY3;CYP1A1;...
Coronavirus disease	-1.78	3.02e-2	215/232 (92.67%)	RPL24;MAPK9;C8A;...
Ferroptosis	-1.82	2.68e-2	36/41 (87.8%)	ACSL1;GCLC;ATG5;...
Protein processing in endoplasmic reticulum	-1.85	2.21e-2	127/171 (74.27%)	AMFR;ATF6;DDOST;...
Protein export	-1.87	1.51e-2	17/23 (73.91%)	SEC63;SEC61A1;SRP9;...
Retinol metabolism	-1.89	1.68e-2	41/68 (60.29%)	ADH1B;AOX1;CYP2B6;...
Ribosome	-2.31	0.00e+0	113/158 (71.52%)	MRPL4;RPL28;MRPL28;...
Complement and coagulation cascades	-2.49	0.00e+0	76/85 (89.41%)	CD59;F5;CR1;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone

Osteosarcoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
U-2 OS	CVCL_0042	Homo sapiens	10uM	6H	Hide ▲