Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMEHRAJ)

Drug Name
Rutin Drug Info
Synonyms
RUTIN; 153-18-4; rutoside; Phytomelin; Quercetin 3-rutinoside; Birutan; Eldrin; Rutin trihydrate; Myrticolorin; Venoruton; Bioflavonoid; Paliuroside; Tanrutin; Osyritrin; Rutine; Rutozyd; 3-Rutinosyl quercetin; 3-Rhamnoglucosylquercetin; Quercetin 3-O-rutinoside; Rutosido; Rutosidum; Rutinum; Globularicitrin; Quercetin-3-rutinoside; Rutabion; Violaquercitrin; Globulariacitrin; Melin; Rutinic acid; Birutan Forte; Birutin; Quercetin rhamnoglucosine; Quercetin-3beta-rutinoside; UNII-5G06TVY3R7; Oxyritin; Rutosid; Ilixanthin; Rutinion acid
Cross-matching ID
PubChem CID
5280805
ChEBI ID
CHEMBL226335
CAS Number
CAS 153-18-4
TTD Drug ID
D09ALJ
VARIDT Drug ID
DR01181
INTEDE Drug ID
DR2149

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
DNA replication 2.25 0.00e+0 34/36 (94.44%) MCM3;POLD1;RPA3;...
Cell cycle 2.16 0.00e+0 110/124 (88.71%) SMC1A;PLK1;CCND1;...
Progesterone-mediated oocyte maturation 2.06 0.00e+0 75/100 (75%) GNAI1;PRKACB;PLK1;...
Fanconi anemia pathway 1.98 0.00e+0 36/54 (66.67%) CENPX;RPA3;FAAP100;...
Toxoplasmosis 1.98 0.00e+0 103/112 (91.96%) GNAI1;CD40;HLA-DPA1;...
Hematopoietic cell lineage 1.92 2.17e-3 90/99 (90.91%) CD1E;CD9;HLA-DPA1;...
Allograft rejection 1.89 5.57e-3 32/38 (84.21%) CD40;HLA-DPA1;HLA-DRA;...
Viral myocarditis 1.87 4.87e-3 53/60 (88.33%) CD40;HLA-DPA1;HLA-DRA;...
Intestinal immune network for IgA production 1.87 4.33e-3 38/48 (79.17%) CD40;HLA-DPA1;HLA-DRA;...
Circadian entrainment 1.84 3.90e-3 85/97 (87.63%) GNAI1;GNAS;PRKACB;...
Homologous recombination 1.83 5.91e-3 35/41 (85.37%) POLD1;RPA3;RAD51C;...
Asthma 1.83 5.41e-3 25/31 (80.65%) CD40;HLA-DPA1;HLA-DRA;...
Nucleotide excision repair 1.81 7.00e-3 40/47 (85.11%) RAD23B;POLD1;RBX1;...
Human immunodeficiency virus 1 infection 1.81 7.43e-3 189/212 (89.15%) GNAI1;CCNB1;MAPK1;...
Long-term depression 1.80 7.80e-3 55/60 (91.67%) GNAI1;GNAS;PLA2G4A;...
Base excision repair 1.79 8.12e-3 29/33 (87.88%) POLD1;SMUG1;PARP2;...
Spinocerebellar ataxia 1.77 9.17e-3 128/143 (89.51%) ATXN10;PIK3CD;GRIA2;...
Autoimmune thyroid disease 1.77 1.16e-2 46/53 (86.79%) CD40;HLA-DPA1;HLA-DRA;...
VEGF signaling pathway 1.76 1.16e-2 50/59 (84.75%) PLA2G4A;MAPK1;PIK3CD;...
Serotonergic synapse 1.74 1.30e-2 97/114 (85.09%) GNAI1;GNAS;PRKACB;...
Non-homologous end-joining 1.72 1.49e-2 11/13 (84.62%) FEN1;DCLRE1C;PRKDC;...
Proteasome 1.72 1.48e-2 44/46 (95.65%) PSMB8;PSMC1;PSMD3;...
Mismatch repair 1.71 1.81e-2 22/23 (95.65%) POLD1;RPA3;MSH6;...
Human T-cell leukemia virus 1 infection 1.69 2.44e-2 197/219 (89.95%) CD40;RELB;PRKACB;...
Oocyte meiosis 1.67 3.01e-2 90/129 (69.77%) SMC1A;PRKACB;PLK1;...
Ribosome biogenesis in eukaryotes 1.66 3.15e-2 52/108 (48.15%) NVL;POP7;SNU13;...
Inflammatory bowel disease 1.66 3.22e-2 58/65 (89.23%) HLA-DPA1;HLA-DRA;HLA-DPB1;...
Relaxin signaling pathway 1.65 3.30e-2 114/129 (88.37%) GNAI1;GNAS;PRKACB;...
Primary immunodeficiency 1.65 3.32e-2 33/38 (86.84%) CD40;CD4;IL2RG;...
Gap junction 1.65 3.51e-2 72/88 (81.82%) GNAI1;PDGFC;GNAS;...
PPAR signaling pathway -1.75 3.58e-2 66/74 (89.19%) ACSL1;CYP27A1;APOC3;...
Mineral absorption -1.78 3.34e-2 48/60 (80%) SLC30A1;MT1HL1;MT1X;...
Complement and coagulation cascades -1.82 2.15e-2 76/85 (89.41%) C4BPA;KNG1;F2R;...
Ferroptosis -1.93 2.15e-2 36/41 (87.8%) MAP1LC3C;SLC3A2;ACSL6;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 6H, 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 6H, 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 6H, 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.01uM - 2.22uM 24H