Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMEJU1L)

Drug Name
Ipsapirone Drug Info
Synonyms
IPSAPIRONE; 95847-70-4; Ipsapironum [Latin]; Ipsapirona [Spanish]; Ipsapirone [INN:BAN]; UNII-6J9B11MN0K; C19H23N5O3S; 2-[4-[4-(2-PYRIMIDINYL)-1-PIPERAZINYL]BUTYL]-1,2-BENZISOTHIAZOL-3(2H)-ONE-1,1-DIOXIDE; BRN 5486134; CHEMBL8412; 6J9B11MN0K; NCGC00025315-01; DSSTox_CID_25688; 2-(4-(4-(2-Pyrimidinyl)-1-piperazinyl)butyl)-1,2-benzisothiazol-3(2H)-one 1,1-dioxide; DSSTox_RID_81060; DSSTox_GSID_45688; Ipsapironum; Ipsapirona; 1,1-dioxo-2-[4-(4-pyrimidin-2-ylpiperazin-1-yl)butyl]-1,2-benzothiazol-3-one
Cross-matching ID
PubChem CID
56971
ChEBI ID
CHEMBL8412
CAS Number
CAS 95847-70-4
TTD Drug ID
D02FNU

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Amino sugar and nucleotide sugar metabolism 1.92 8.98e-3 38/48 (79.17%) AMDHD2;UAP1;MPI;...
DNA replication 1.92 4.49e-3 34/36 (94.44%) RFC2;POLE3;MCM7;...
Ribosome biogenesis in eukaryotes 1.86 1.20e-2 52/108 (48.15%) IMP3;NVL;FBL;...
Nucleotide excision repair 1.76 4.26e-2 40/47 (85.11%) RFC2;DDB1;POLE3;...
Antigen processing and presentation -2.00 3.63e-3 60/78 (76.92%) HLA-DPB1;HLA-DOB;CTSL;...
Complement and coagulation cascades -2.00 5.45e-3 76/85 (89.41%) F7;MASP2;KLKB1;...
Steroid hormone biosynthesis -2.34 0.00e+0 43/61 (70.49%) HSD11B1;CYP3A7;CYP1A2;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H, 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H, 24H