Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMEK6WX)

Drug Name
4-(2-AMINOETHYL)BENZENESULFONAMIDE Drug Info
Synonyms
4-(2-Aminoethyl)benzenesulfonamide; 35303-76-5; 4-(2-aminoethyl)benzene-1-sulfonamide; 4-(2-Aminoethyl)benzene sulfonamide; 4-(2-Amino-ethyl)-benzenesulfonamide; Benzenesulfonamide, 4-(2-aminoethyl)-; 4-(2-Aminoethyl)benzenesulphonamide; CHEMBL7087; 4-aminoethylbenzenesulfonamide; 2-(4-sulfamoylphenyl)ethylamine; 4-(2-Aminoethyl)benzesulfonamide; FXNSVEQMUYPYJS-UHFFFAOYSA-N; 4-(2-Aminoethyl) Benzenesulfonamide; MFCD00010301; 4-(2-aminoethyl)-benzenesulfonamide hydrochloride; EINECS 252-501-0
Cross-matching ID
PubChem CID
169682
ChEBI ID
CHEMBL7087
CAS Number
CAS 35303-76-5
TTD Drug ID
D04NSN

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Retinol metabolism 2.11 0.00e+0 41/68 (60.29%) ADH1C;ALDH1A1;UGT2A3;...
Proteasome 1.96 5.29e-3 44/46 (95.65%) PSMD3;PSMA4;PSMD2;...
Cell cycle 1.77 4.44e-2 110/124 (88.71%) CDK6;PCNA;CCND2;...
ECM-receptor interaction -1.78 2.48e-2 80/88 (90.91%) AGRN;SDC4;LAMA3;...
Biosynthesis of unsaturated fatty acids -1.85 1.19e-2 21/27 (77.78%) HACD1;HSD17B12;ELOVL6;...
Salivary secretion -1.86 1.59e-2 76/93 (81.72%) KCNMA1;ADCY7;PLCB2;...
Protein digestion and absorption -1.99 0.00e+0 78/103 (75.73%) COL11A2;COL10A1;COL6A3;...
Steroid biosynthesis -2.44 0.00e+0 19/20 (95%) SC5D;NSDHL;EBP;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 20uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H