Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMEKAYI)

Drug Name
Netupitant Drug Info
Synonyms R-1124; NK1 antagonist (emesis), Roche; Ro-67-3189
Cross-matching ID
PubChem CID
6451149
ChEBI ID
CHEMBL85155
CAS Number
CAS 290297-26-6
TTD Drug ID
D0G3YC
INTEDE Drug ID
DR1141

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Bile secretion 2.13 0.00e+0 68/90 (75.56%) ADCY1;ABCC4;ATP1A2;...
Linoleic acid metabolism 2.00 0.00e+0 21/29 (72.41%) PLAAT3;CYP2C9;CYP2C8;...
Phenylalanine metabolism 1.91 7.78e-3 14/17 (82.35%) MAOB;GLYAT;DDC;...
alpha-Linolenic acid metabolism 1.89 8.75e-3 17/25 (68%) PLAAT3;ACOX1;ACAA1;...
Prostate cancer 1.85 1.17e-2 93/97 (95.88%) NKX3-1;PLAT;GSK3B;...
Caffeine metabolism 1.76 4.08e-2 5/6 (83.33%) NAT2;CYP1A2;NAT1
Biosynthesis of unsaturated fatty acids 1.75 3.83e-2 21/27 (77.78%) SCD;FADS1;ACOX1;...
Selenocompound metabolism 1.73 4.08e-2 11/17 (64.71%) PAPSS2;CTH;SEPHS2;...
PPAR signaling pathway 1.73 3.76e-2 66/74 (89.19%) SCD;HMGCS1;FABP1;...
Complement and coagulation cascades 1.72 4.08e-2 76/85 (89.41%) CFB;CFH;PLAT;...
Riboflavin metabolism -1.63 4.78e-2 7/8 (87.5%) ACP1;ACP5;BLVRB
Galactose metabolism -1.65 4.88e-2 26/31 (83.87%) PFKM;GAA;GALE;...
Ribosome -1.66 4.88e-2 113/158 (71.52%) RPS25;RPL30;RPS15;...
Nucleotide excision repair -1.67 4.73e-2 40/47 (85.11%) RBX1;PCNA;ERCC8;...
Fructose and mannose metabolism -1.72 2.77e-2 30/33 (90.91%) ENOSF1;PFKM;ALDOA;...
Asthma -1.73 2.72e-2 25/31 (80.65%) TNF;HLA-DRA;HLA-DMB;...
Pentose phosphate pathway -1.74 2.74e-2 25/30 (83.33%) PFKM;ALDOA;RBKS;...
RNA polymerase -1.78 2.06e-2 23/31 (74.19%) POLR2K;POLR2G;POLR1E;...
Viral myocarditis -1.83 1.53e-2 53/60 (88.33%) CCND1;RAC3;BID;...
Autoimmune thyroid disease -1.85 5.49e-3 46/53 (86.79%) FAS;CD80;CTLA4;...
Intestinal immune network for IgA production -1.91 3.29e-3 38/48 (79.17%) CCR10;HLA-DRA;ICOS;...
Hematopoietic cell lineage -1.96 2.06e-3 90/99 (90.91%) IL11;IL7;HLA-DOA;...
Type I diabetes mellitus -2.11 0.00e+0 38/43 (88.37%) IL12A;LTA;PTPRN;...
Allograft rejection -2.13 0.00e+0 32/38 (84.21%) FAS;CD80;TNF;...
Graft-versus-host disease -2.19 0.00e+0 32/42 (76.19%) FAS;CD80;KLRD1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.04uM - 10uM 24H