Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMEMBJC)

• Drug Name: Folic Acid Drug Info
• Synonyms: folic acid; 59-30-3; Folate; Pteroylglutamic acid; Vitamin M; Folacin; Folacid; PteGlu; Vitamin B9; Folvite; Pteroyl-L-glutamic acid; Vitamin Bc; Acifolic; Cytofol; Incafolic; Foliamin; Folsaure; Folicet; Millafol; Folipac; Folettes; Folsan; Folbal; Folsav; Vitamin Be; Pteroyl-L-monoglutamic acid; Mittafol; Folan; Facid; Pteroylmonoglutamic acid; Antianemia factor; Factor U; Folico (Italy); Folina (Italy); Foldine [France]; Pteroylmonoglutamate; Acfol (Spain); Foldine; Folcysteine; Folasic (Australia); Folcidin; Folaemin [Netherlands]; Nifolin; [3H]folic acid
• Therapeutic Class: Vitamins
• Cross-matching ID:
  PubChem CID: 135398658
  ChEBI ID: CHEMBL1622
  CAS Number: CAS 59-30-3
  TTD Drug ID: D0Z0DW
  VARIDT Drug ID: DR00134
  INTEDE Drug ID: DR0742
  ACDINA Drug ID: D00291

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Type I diabetes mellitus	-1.65	4.97e-2	38/43 (88.37%)	GZMB;HLA-DRB1;HLA-DPA1;...
Asthma	-1.68	4.16e-2	25/31 (80.65%)	FCER1A;HLA-DRB1;HLA-DPA1;...
Amino sugar and nucleotide sugar metabolism	-1.68	4.33e-2	38/48 (79.17%)	RENBP;NANS;GALE;...
Synaptic vesicle cycle	-1.69	4.14e-2	63/78 (80.77%)	ATP6V0B;DNM3;SLC18A2;...
Th1 and Th2 cell differentiation	-1.69	4.17e-2	80/92 (86.96%)	IL13;DLL3;JAG1;...
Mitophagy	-1.70	3.77e-2	56/68 (82.35%)	RELA;GABARAPL1;CSNK2A2;...
Glutathione metabolism	-1.71	3.68e-2	43/57 (75.44%)	GPX4;ODC1;G6PD;...
Fc gamma R-mediated phagocytosis	-1.74	2.56e-2	79/97 (81.44%)	ARPC5L;PRKCA;FCGR2B;...
Renin-angiotensin system	-1.75	2.79e-2	20/23 (86.96%)	KLK2;AGT;MME;...
Allograft rejection	-1.79	1.60e-2	32/38 (84.21%)	GZMB;HLA-DRB1;HLA-DPA1;...
Ferroptosis	-1.81	1.36e-2	36/41 (87.8%)	NCOA4;PCBP2;ATG5;...
Primary immunodeficiency	-1.84	9.20e-3	33/38 (86.84%)	CD19;IL2RG;IGLL1;...
Peroxisome	-1.85	8.76e-3	72/82 (87.8%)	FAR2;PEX19;AMACR;...
NF-kappa B signaling pathway	-1.86	1.02e-2	90/104 (86.54%)	PLCG2;RIPK1;RELA;...
Rheumatoid arthritis	-1.87	1.23e-2	78/93 (83.87%)	IL15;ATP6V0B;TCIRG1;...
Hematopoietic cell lineage	-1.92	9.20e-3	90/99 (90.91%)	DNTT;KITLG;IL7R;...
Arachidonic acid metabolism	-1.97	0.00e+0	48/61 (78.69%)	PLA2G4C;PTGES3;PTGS1;...
Glycine, serine and threonine metabolism	-1.99	0.00e+0	31/40 (77.5%)	PSPH;DLD;ALDH7A1;...
Collecting duct acid secretion	-2.07	0.00e+0	22/27 (81.48%)	TCIRG1;ATP6V1D;SLC12A7;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	0.04uM - 10uM	6H, 24H	Hide ▲

Cervix

Cervical adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HeLa	CVCL_0030	Homo sapiens	0.01uM - 10uM	3H, 24H	Hide ▲

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Pancreas

Pancreatic carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
YAPC	CVCL_1791	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	0.01uM - 10uM	24H	Show ▼