Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMEMV9D)

Drug Name
Trimeprazine Drug Info
Synonyms
Alimemazina; Alimemazine; Alimemazinum; Alimezine; Isobutrazine; Methylpromazine; Oxomemazin; Repetin; Teralen; Trimeperazine; Trimeprazine Tartrat; Bayer 1219; Alimemazina [INN-Spanish]; Alimemazine (INN); Alimemazine [INN:BAN]; Alimemazinum [INN-Latin]; Dl-Trimeprazine; Nedeltran (TN); Oxomemazine [DCF:INN]; Panectyl (TN); Repeltin (TN); Temaril (TN); Therafene (TN); Theralen (TN); Theralene (TN); Trimeprazine (BAN); Vallergan (TN); Vanectyl (TN); Trimeprazine 5,5-dioxide; Trimeprazine hemi-(+)-tartrate; N,N,beta-Trimethyl-10H-phenothiazine-10-propanamine; N,N,2-trimethyl-3-phenothiazin-10-ylpropan-1-amine; N,N,2-trimethyl-3-(10H-phenothiazin-10-yl)propan-1-amine; (+-)-Alimemazine; (+-)-Trimeprazine; 10-(2-Methyl-3-dimethylaminopropyl)-phenothiazine; 10-(3-(Dimethylamino)-2-methylpropyl)phenothiazine; 10-(3-Dimethylamino-2-methylpropyl)phenothiazine
Therapeutic ClassAntihistamines
Cross-matching ID
PubChem CID
5574
ChEBI ID
CHEMBL829
CAS Number
CAS 84-96-8
TTD Drug ID
D08HZL

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Steroid biosynthesis 2.51 0.00e+0 19/20 (95%) DHCR24;MSMO1;DHCR7;...
Terpenoid backbone biosynthesis 2.07 0.00e+0 18/22 (81.82%) HMGCS1;IDI1;FDPS;...
Biosynthesis of unsaturated fatty acids 1.92 3.41e-3 21/27 (77.78%) SCD;FADS2;FADS1;...
Steroid hormone biosynthesis 1.89 1.28e-2 43/61 (70.49%) CYP1B1;HSD17B7;HSD11B1;...
Cortisol synthesis and secretion 1.88 1.02e-2 58/65 (89.23%) LDLR;GNA11;PLCB1;...
Lysosome 1.83 1.71e-2 115/128 (89.84%) MCOLN1;TPP1;PSAP;...
Retinol metabolism 1.78 2.49e-2 41/68 (60.29%) ALDH1A1;AOX1;ALDH1A2;...
Complement and coagulation cascades 1.78 2.30e-2 76/85 (89.41%) TFPI;CLU;CFB;...
PPAR signaling pathway 1.77 2.62e-2 66/74 (89.19%) HMGCS1;SCD;FADS2;...
Ovarian steroidogenesis 1.74 3.17e-2 41/51 (80.39%) CYP1B1;HSD17B7;LDLR;...
Primary bile acid biosynthesis 1.73 3.26e-2 15/17 (88.24%) CH25H;CYP39A1;ACOX2;...
Synthesis and degradation of ketone bodies 1.71 3.58e-2 9/10 (90%) HMGCS1;ACAT2;ACAT1
Sphingolipid metabolism 1.69 4.72e-2 32/49 (65.31%) PSAP;NEU1;SGMS1;...
Spliceosome -1.73 3.75e-2 101/150 (67.33%) RBM22;ACIN1;DHX15;...
DNA replication -1.76 2.63e-2 34/36 (94.44%) RPA1;SSBP1;MCM3;...
Small cell lung cancer -1.79 2.26e-2 90/92 (97.83%) TRAF3;MAX;CCND1;...
Ribosome biogenesis in eukaryotes -1.79 2.71e-2 52/108 (48.15%) GNL3L;GTPBP4;GNL2;...
Ribosome -1.79 3.39e-2 113/158 (71.52%) RPL13A;RPS6;RPL27;...
Cytosolic DNA-sensing pathway -1.84 3.23e-2 52/63 (82.54%) POLR2H;MAVS;CXCL10;...
Proximal tubule bicarbonate reclamation -1.84 4.84e-2 21/23 (91.3%) SLC4A4;GLS;PCK1;...
RNA polymerase -2.12 0.00e+0 23/31 (74.19%) POLR1E;POLR2C;POLR2H;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H, 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H, 24H