Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMENHCI)

Drug Name
Kawain Drug Info
Synonyms
kavain; 3155-48-4; DL-KAWAIN; Neuronica; Cavain; DL-Kavain; 1635-33-2; MLS000069449; SMR000059008; 2H-Pyran-2-one, 5,6-dihydro-4-methoxy-6-(2-phenylethenyl)-; Gonosan; 2H-Pyran-2-one, 5,6-dihydro-4-methoxy-6-styryl-; kavaine; trans-5,6-Dihydro-4-methoxy-6-(2-phenylethenyl)-2H-pyran-2-one; C14H14O3; rac-Kavain; 2,6-Heptadienoic acid, 5-hydroxy-3-methoxy-7-phenyl-, delta-lactone; D,L-Kawin; Kawain, DL-; Kawain (+-)-form; DL-Kavain, primary pharmaceutical reference standard; kavain, (R)-(E)-isomer; EINECS 207-907-2; CCRIS 9373
Cross-matching ID
PubChem CID
5281565
ChEBI ID
CHEMBL6117
CAS Number
CAS 500-64-1
TTD Drug ID
D0L1WV

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Tryptophan metabolism 1.97 1.07e-2 35/42 (83.33%) KMO;DHTKD1;ALDH9A1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 8uM - 20uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H, 24H
Fibroblast
Nasopharyngeal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
FIBRNPC CVCL_UK07 Homo sapiens 10uM 6H, 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H, 24H