Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMEOS5K)

Drug Name
AEE-788 Drug Info
Synonyms AEE; AEE 788; AEE788; GNF-Pf-5343; AEE-788, NVP-AEE 788, AEE788
Therapeutic ClassAnticancer Agents
Cross-matching ID
PubChem CID
10297043
ChEBI ID
CHEMBL587723
CAS Number
CAS 497839-62-0
TTD Drug ID
D0G2QH

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Mucin type O-glycan biosynthesis 1.84 4.18e-2 20/36 (55.56%) GALNT7;ST6GALNAC2;B4GALT5;...
Propanoate metabolism 1.76 4.97e-2 30/34 (88.24%) DLD;ACOX3;ALDH6A1;...
Ribosome biogenesis in eukaryotes -1.84 3.94e-2 52/108 (48.15%) RBM28;IMP3;GAR1;...
Complement and coagulation cascades -1.86 3.87e-2 76/85 (89.41%) PLAT;FGA;SERPIND1;...
ECM-receptor interaction -1.95 2.49e-2 80/88 (90.91%) ITGA3;ITGB1;ITGB5;...
Spliceosome -2.06 0.00e+0 101/150 (67.33%) SNRPG;PRPF19;HSPA1A;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H