Details of the Drug Pharmacogenomic Perturbation Atlas

THIOCOLCHICOSIDE Drug Info

Thiocolchicoside; 602-41-5; Coltramyl; UNII-T1X8S697GT; Thiocolchicine 2-glucoside analog; NSC 147755; Musco-ril; T1X8S697GT; 10-Thiocolchicoside; Tiocolchicoside [DCIT]; Colchicoside, 10-thio-; Thiocolchicoside [INN:DCF]; Q-201823; Thiocolchicosidum [INN-Latin]; Tiocolchicosido [INN-Spanish]; C27H33NO10S; Tiocolchicosido; Tiocolchicoside; Muscoril; Thiocolchicosidum; EINECS 210-017-7; BRN 0072205; R. 271; 2-10-Di(demethoxy)-2-glucosyloxy-10-methylthiocolchicine; Miotens; Coltrax; NSC147755; Coltramyl (TN); NCGC00016519-01

Cross-matching ID

PubChem CID

9915886

ChEBI ID

CHEMBL213907

CAS Number

CAS 602-41-5

TTD Drug ID

D0IG4I

General Information of Drug (ID: DMEPWYA)

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Propanoate metabolism	2.00	6.52e-3	30/34 (88.24%)	ABAT;ACAT1;ACAT2;...
Cell cycle	1.92	1.63e-2	110/124 (88.71%)	CCNE2;WEE1;CDC20;...
Synthesis and degradation of ketone bodies	1.83	2.83e-2	9/10 (90%)	ACAT1;ACAT2;HMGCS2;...
Butanoate metabolism	1.80	2.93e-2	23/28 (82.14%)	ABAT;ACAT1;ALDH5A1;...
Steroid biosynthesis	1.73	4.56e-2	19/20 (95%)	SC5D;MSMO1;SQLE;...
Valine, leucine and isoleucine degradation	1.72	4.35e-2	42/48 (87.5%)	ABAT;ACAD8;AUH;...
Glycerolipid metabolism	-1.72	3.64e-2	44/61 (72.13%)	AGPAT1;PLPP2;DGKZ;...
Malaria	-1.76	2.89e-2	44/50 (88%)	THBS1;CSF3;COMP;...
Fructose and mannose metabolism	-1.77	2.78e-2	30/33 (90.91%)	GMDS;KHK;GMPPA;...
PPAR signaling pathway	-1.77	3.09e-2	66/74 (89.19%)	MMP1;ACOX2;SLC27A6;...
Cocaine addiction	-1.78	2.98e-2	42/49 (85.71%)	DDC;RELA;GRIN2A;...
Pentose phosphate pathway	-1.81	2.65e-2	25/30 (83.33%)	GPI;ALDOB;PGLS;...
Inflammatory bowel disease	-1.81	2.87e-2	58/65 (89.23%)	SMAD2;TLR2;NFKB1;...
Nicotine addiction	-1.83	2.91e-2	32/40 (80%)	GABRB3;GABRG2;GRIN2A;...
TNF signaling pathway	-1.87	1.99e-2	103/112 (91.96%)	TRAF2;IRF1;FOS;...
Rheumatoid arthritis	-1.88	2.21e-2	78/93 (83.87%)	ATP6V1F;MMP1;TGFB1;...
Galactose metabolism	-1.94	6.62e-3	26/31 (83.87%)	GLA;AKR1B1;AKR1B10;...
Staphylococcus aureus infection	-2.08	0.00e+0	72/95 (75.79%)	KRT16;KRT23;DEFA6;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone

Osteosarcoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
U-2 OS	CVCL_0042	Homo sapiens	3.33uM	6H

Bone marrow

Neuroblastoma

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	0.01uM - 10uM	6H, 24H

Cervix

Cervical adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HeLa	CVCL_0030	Homo sapiens	0.01uM - 10uM	3H, 24H

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	0.04uM - 10uM	6H, 24H

Hematopoietic system

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
ASC	CVCL_U602	Homo sapiens	10uM	24H

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	0.01uM - 10uM	6H, 24H

Liver

Hepatoblastoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Hep G2	CVCL_0027	Homo sapiens	10uM	6H

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	0.01uM - 10uM	6H, 24H

Non-small cell lung carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HCC515	CVCL_5134	Homo sapiens	10uM	6H, 24H

Pancreas

Pancreatic carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
YAPC	CVCL_1791	Homo sapiens	0.01uM - 10uM	24H

Prostate

Prostate carcinoma

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	0.01uM - 10uM	6H, 24H