Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMES906)

Drug Name
3,7,3',4'-TETRAHYDROXYFLAVONE Drug Info
Synonyms
Fisetin; 528-48-3; 2-(3,4-Dihydroxyphenyl)-3,7-dihydroxy-4H-chromen-4-one; 5-Desoxyquercetin; Fustel; Cotinin; Viset; 3,3',4',7-Tetrahydroxyflavone; Fisetholz; Superfustel; Fustet; Fietin; Junger fustik; 3,7,3',4'-Tetrahydroxyflavone; Ventin sumach; Zante fustic; Young fustic; Superfustel K; Ungarisches gelbholz; CI Natural Brown 1; Young fustic crystals; Bois bleu de Honqrie; BOIS bleude honqrie; CI 75620; NSC 407010; NSC 656275; 5-Deoxyquercetin; 2-(3,4-Dihydroxyphenyl)-3,7-dihydroxy-4H-1-benzopyran-4-one; Natural Brown 1; FISETIN
Cross-matching ID
PubChem CID
5281614
ChEBI ID
CHEMBL31574
CAS Number
CAS 528-48-3
TTD Drug ID
D0MF5Y

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Arrhythmogenic right ventricular cardiomyopathy 1.95 3.32e-2 70/77 (90.91%) ITGA3;ITGB4;CDH2;...
Dilated cardiomyopathy 1.91 2.21e-2 86/96 (89.58%) ITGA3;TGFB1;ITGB4;...
Focal adhesion 1.90 1.47e-2 180/201 (89.55%) COL4A1;PXN;PDGFA;...
Basal cell carcinoma 1.87 1.38e-2 41/63 (65.08%) TCF7;TP53;DVL1;...
Hypertrophic cardiomyopathy 1.77 4.87e-2 81/90 (90%) ITGA3;TGFB1;ITGB4;...
Legionellosis -1.60 4.50e-2 51/57 (89.47%) IL6;BCL2L13;CXCL1;...
Ribosome -1.61 4.24e-2 113/158 (71.52%) RPL23A;RPS7;RPS27A;...
Prion disease -1.61 4.41e-2 209/273 (76.56%) PSMD6;PSMC3;NCAM2;...
Rheumatoid arthritis -1.62 4.21e-2 78/93 (83.87%) ATP6V1C1;ATP6V1B2;TNFSF13;...
Type I diabetes mellitus -1.63 4.20e-2 38/43 (88.37%) PTPRN2;HLA-DMB;HLA-DPA1;...
Phagosome -1.64 4.13e-2 118/152 (77.63%) TLR2;DYNC1I2;ATP6V0A2;...
Autoimmune thyroid disease -1.64 4.16e-2 46/53 (86.79%) HLA-DMB;HLA-DPA1;HLA-B;...
Complement and coagulation cascades -1.68 3.24e-2 76/85 (89.41%) CFHR2;CFD;PLAU;...
SNARE interactions in vesicular transport -1.69 3.02e-2 19/33 (57.58%) STX3;STX17;STX11;...
Staphylococcus aureus infection -1.70 2.91e-2 72/95 (75.79%) DEFB1;CAMP;C3;...
Huntington disease -1.74 1.95e-2 233/306 (76.14%) ATP5PB;POLR2A;ADRM1;...
Graft-versus-host disease -1.77 1.23e-2 32/42 (76.19%) HLA-DMB;HLA-DPA1;HLA-B;...
Non-alcoholic fatty liver disease -1.77 1.26e-2 126/155 (81.29%) BCL2L11;PRKAG2;NDUFB7;...
Allograft rejection -1.79 1.10e-2 32/38 (84.21%) HLA-DMB;HLA-DPA1;HLA-B;...
Amyotrophic lateral sclerosis -1.90 3.37e-3 267/364 (73.35%) RAE1;DNAH6;PSMD6;...
Antigen processing and presentation -1.93 1.29e-3 60/78 (76.92%) CTSB;RFXAP;HSPA1L;...
Proteasome -1.93 1.50e-3 44/46 (95.65%) SEM1;PSMA4;PSMD8;...
Parkinson disease -1.94 1.80e-3 176/249 (70.68%) PSMD6;PSMC3;NDUFB7;...
Asthma -1.96 2.25e-3 25/31 (80.65%) HLA-DMB;HLA-DPA1;FCER1G;...
Nucleotide excision repair -1.97 3.00e-3 40/47 (85.11%) RFC1;RFC2;RPA3;...
Oxidative phosphorylation -2.04 0.00e+0 93/133 (69.92%) ATP6V1C1;NDUFB7;ATP6V1B2;...
Protein processing in endoplasmic reticulum -2.05 0.00e+0 127/171 (74.27%) PREB;VCP;RNF5;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H