Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMES9Q2)

Drug Name
Ginsenoside Rc Drug Info
Synonyms
Ginsenoside Rc; Panaxoside RC; ginsenoside-Rc; 0K83B0L786; 11021-14-0; 20-((6-O-alpha-L-Arabinofuranosyl-beta-D-glucopyranosyl)oxy)-12beta-hydroxydammar-24-en-3beta-yl 2-O-beta-D-glucopyranosyl-beta-D-glucopyranoside; 20-[(6-O-a-L-arabinofuranosyl-ss-D-glucopyranosyl)oxy]-12ss-hydroxydammar-24-en-3ss-yl 2-O-ss-D-glucopyranosyl-ss-D-glucopyranoside; AB0029025; AKOS037514670; AS-56539; BRN 1677618; CHEBI:77154; CHEMBL451702; CS-3837; EINECS 234-253-5; HY-N0042; MFCD00133368; NCGC00485983-01; NSC 310104; UNII-0K83B0L786; s9266
Cross-matching ID
PubChem CID
12855889
ChEBI ID
CHEMBL77154
CAS Number
CAS 11021-14-0
INTEDE Drug ID
DR2677

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Ribosome 2.15 0.00e+0 113/158 (71.52%) RPS4Y1;MRPL23;MRPL17;...
Oxidative phosphorylation 2.01 0.00e+0 93/133 (69.92%) ATP5MG;SDHD;ATP6V1B1;...
African trypanosomiasis 1.84 1.95e-2 32/37 (86.49%) APOA1;IL1B;TNF;...
Proteasome 1.84 1.88e-2 44/46 (95.65%) PSMA1;PSMF1;PSME4;...
Hematopoietic cell lineage 1.78 3.17e-2 90/99 (90.91%) CD1E;CD2;CD3D;...
Citrate cycle (TCA cycle) 1.76 3.48e-2 30/30 (100%) SDHD;SUCLG2;IDH1;...
Protein export 1.73 3.58e-2 17/23 (73.91%) OXA1L;SEC11A;SRPRA;...
Huntington disease 1.72 3.96e-2 233/306 (76.14%) GPX3;CYCS;PSMA1;...
Mucin type O-glycan biosynthesis -1.97 2.32e-2 20/36 (55.56%) GALNT1;B3GNT3;ST6GALNAC4;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H