Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMEWZ80)

Drug Name
ICI-199441 Drug Info
Synonyms
115199-84-3; ICI-199,441 HYDROCHLORIDE; ICI 199,441 hydrochloride; Ici 199441; Ici 199,441; AC1MIZCX; N-(2-(N-Methyl-3,4-dichlorophenylacetamido)-2-phenylethyl)pyrrolidine; SCHEMBL7647023; CTK8E9897; MolPort-023-275-929; AKOS024458644; (S)-3,4-Dichloro-N-methyl-N-(1-phenyl-2-(1-pyrrolidinyl)ethyl)benzeneacetamide monohydrochloride; RT-013313; B6448; J-003264; Benzeneacetamide, 3,4-dichloro-N-methyl-N-(1-phenyl-2-(1-pyrrolidinyl)ethyl)-, monohydrochloride, (S)-
Cross-matching ID
PubChem CID
3082718
ChEBI ID
CHEMBL38576
CAS Number
CAS 116508-24-8
TTD Drug ID
D03SAV

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Steroid biosynthesis 2.46 0.00e+0 19/20 (95%) MSMO1;LSS;SQLE;...
PPAR signaling pathway 2.20 0.00e+0 66/74 (89.19%) SCD;HMGCS1;FADS2;...
Terpenoid backbone biosynthesis 2.03 7.08e-3 18/22 (81.82%) FDPS;HMGCS1;HMGCR;...
Cholesterol metabolism 1.98 5.31e-3 44/50 (88%) PLTP;ABCA1;TSPO;...
Complement and coagulation cascades 1.89 1.27e-2 76/85 (89.41%) CFB;F3;TFPI;...
Biosynthesis of unsaturated fatty acids 1.88 1.06e-2 21/27 (77.78%) SCD;FADS2;FADS1;...
Glycerolipid metabolism 1.83 1.52e-2 44/61 (72.13%) AKR1B10;PLPP3;MGLL;...
Steroid hormone biosynthesis 1.79 2.26e-2 43/61 (70.49%) AKR1C3;HSD17B7;HSD17B2;...
Pentose phosphate pathway 1.73 3.89e-2 25/30 (83.33%) PGD;ALDOC;TKTL1;...
Peroxisome 1.72 4.14e-2 72/82 (87.8%) IDH1;SOD2;PRDX1;...
Ferroptosis 1.72 3.96e-2 36/41 (87.8%) CP;GPX4;MAP1LC3B;...
Ribosome -1.80 3.73e-2 113/158 (71.52%) MRPL12;MRPS15;MRPL17;...
Ribosome biogenesis in eukaryotes -1.95 0.00e+0 52/108 (48.15%) REXO5;TBL3;GTPBP4;...
×

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H