Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMEZO4M)

Drug Name
G6976 Drug Info
Synonyms
12H-Indolo[2,3-a]pyrrolo[3,4-c]carbazole-12-propanenitrile, 5,6,7,13-tetrahydro-13-methyl-5-oxo-; Go 6976; 136194-77-9; GO6976; Go-6976; Goe 6976; UNII-B9IQO7JZ16; 6976; Go 6976, Solution; B9IQO7JZ16; 5,6,7,13-Tetrahydro-13-Methyl-5-oxo-12H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-12-propanenitrile; CHEMBL302449; CHEBI:51913; 12-(2-Cyanoethyl)-6,7,12,13-tetrahydro-13-methyl-5-oxo-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole; 12-(2-Cyanoethyl)-6,7,12,13-tetrahydro-13-methyl-5-oxo-5H-indolo(2,3-a)pyrrolo(3,4-c)-carbazole; Go6976
Cross-matching ID
PubChem CID
3501
ChEBI ID
CHEMBL302449
CAS Number
CAS 136194-77-9
TTD Drug ID
D08JPU

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Oxidative phosphorylation 2.56 0.00e+0 93/133 (69.92%) COX7B;NDUFA4;NDUFB1;...
p53 signaling pathway 2.24 0.00e+0 63/73 (86.3%) DDB2;CDKN1A;FAS;...
Non-alcoholic fatty liver disease 2.19 2.71e-3 126/155 (81.29%) DDIT3;FAS;ATF4;...
Synthesis and degradation of ketone bodies 2.15 2.03e-3 9/10 (90%) HMGCS1;BDH1;HMGCL;...
Ribosome 2.14 1.63e-3 113/158 (71.52%) RPS27L;RSL24D1;RPS5;...
Butanoate metabolism 1.89 4.07e-3 23/28 (82.14%) ALDH5A1;HMGCS1;BDH1;...
Cysteine and methionine metabolism 1.87 3.49e-3 43/50 (86%) CBS;PHGDH;PSAT1;...
One carbon pool by folate 1.84 7.12e-3 15/20 (75%) SHMT2;MTHFD2;TYMS;...
Glycine, serine and threonine metabolism 1.83 6.33e-3 31/40 (77.5%) CBS;PHGDH;SHMT2;...
Valine, leucine and isoleucine degradation 1.81 8.95e-3 42/48 (87.5%) HMGCS1;ACADM;HADH;...
Alanine, aspartate and glutamate metabolism 1.79 1.04e-2 27/37 (72.97%) ASNS;ASS1;ALDH5A1;...
Riboflavin metabolism 1.76 1.42e-2 7/8 (87.5%) RFK;ENPP1;BLVRB;...
Thyroid cancer 1.69 3.26e-2 36/37 (97.3%) DDB2;CDKN1A;GADD45A;...
Glycosylphosphatidylinositol (GPI)-anchor biosynthesis 1.67 3.60e-2 20/26 (76.92%) PIGV;PIGF;PIGK;...
Caffeine metabolism 1.66 3.53e-2 5/6 (83.33%) CYP1A2;CYP2A6;NAT1
Primary immunodeficiency 1.66 3.76e-2 33/38 (86.84%) CD3E;CD8A;CD79A;...
Parkinson disease 1.65 3.78e-2 176/249 (70.68%) DDIT3;PRKACB;ATF4;...
Thermogenesis 1.62 4.48e-2 173/232 (74.57%) PRKACB;COX7B;NDUFA4;...
Toxoplasmosis -1.66 4.79e-2 103/112 (91.96%) RELA;MAPK10;NFKBIA;...
Focal adhesion -1.71 4.19e-2 180/201 (89.55%) LAMA5;GRB2;CAPN2;...
ECM-receptor interaction -1.72 4.27e-2 80/88 (90.91%) LAMC1;LAMB2;LAMA2;...
Axon guidance -1.72 4.38e-2 151/182 (82.97%) PARD3;MYL9;PAK4;...
Viral myocarditis -1.73 4.36e-2 53/60 (88.33%) ABL2;EIF4G3;FYN;...
Carbohydrate digestion and absorption -1.76 3.96e-2 37/47 (78.72%) AKT1;PLCB4;CACNA1D;...
Melanogenesis -1.80 3.17e-2 74/101 (73.27%) MAPK1;FZD8;GNAI3;...
Amoebiasis -1.83 2.55e-2 99/102 (97.06%) LAMA5;IFNG;PTK2;...
Notch signaling pathway -1.91 7.54e-3 49/59 (83.05%) TLE3;NUMB;NOTCH1;...
Complement and coagulation cascades -1.96 5.66e-3 76/85 (89.41%) TFPI;C5AR1;THBD;...
Aldosterone-regulated sodium reabsorption -2.23 0.00e+0 34/37 (91.89%) KCNJ1;MAPK1;ATP1B1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.04uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.04uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.04uM - 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 0.04uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.04uM - 10uM 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 0.04uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.04uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.04uM - 10uM 24H