Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMEZVGK)

Drug Name
DAU-5884 Drug Info
Synonyms 131780-47-7
Cross-matching ID
PubChem CID
16759154
CAS Number
CAS 131780-47-7
TTD Drug ID
D0R8AZ

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
DNA replication 2.05 0.00e+0 34/36 (94.44%) POLE2;PCNA;RFC2;...
Nicotine addiction 2.01 3.97e-3 32/40 (80%) GABRP;GRIA2;GABRA1;...
Mismatch repair 2.01 2.64e-3 22/23 (95.65%) PCNA;RFC2;POLD1;...
Base excision repair 1.82 1.98e-2 29/33 (87.88%) POLE2;PCNA;POLD1;...
Ribosome 1.75 3.49e-2 113/158 (71.52%) RPS4Y1;RPS5;MRPS2;...
Pyrimidine metabolism 1.71 3.83e-2 40/56 (71.43%) RRM2;TYMS;CDA;...
Fanconi anemia pathway 1.71 3.51e-2 36/54 (66.67%) BLM;USP1;RPA1;...
Mannose type O-glycan biosynthesis 1.68 3.97e-2 14/23 (60.87%) B4GALT1;B4GAT1;POMGNT1;...
Mucin type O-glycan biosynthesis 1.66 4.58e-2 20/36 (55.56%) B4GALT5;GALNT14;GALNT3;...
Progesterone-mediated oocyte maturation 1.65 4.76e-2 75/100 (75%) PLK1;ADCY2;CCNA2;...
IL-17 signaling pathway 1.64 4.47e-2 84/94 (89.36%) S100A9;LCN2;S100A8;...
Lysosome -1.76 4.83e-2 115/128 (89.84%) CTSD;ATP6AP1;PPT2;...
Complement and coagulation cascades -2.19 0.00e+0 76/85 (89.41%) C4BPB;PROCR;PROC;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H