General Information of Drug (ID: DMF0NA9)

Drug Name
KX-01 Drug Info
Cross-matching ID
PubChem CID
23635314
TTD Drug ID
D0TY3L

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name NES FDR q-val Tag % Leading Edge Genes
Focal adhesion 2.12 0.00e+0 180/201 (89.55%) ITGA6;CAV1;ACTN1;...
Amoebiasis 2.09 0.00e+0 99/102 (97.06%) CXCL2;CXCL3;ACTN1;...
Bacterial invasion of epithelial cells 1.97 4.40e-3 59/77 (76.62%) CAV1;ITGA5;ILK;...
Chagas disease 1.94 3.30e-3 93/102 (91.18%) CXCL8;TGFB1;GNA11;...
Salmonella infection 1.93 5.28e-3 198/249 (79.52%) PODXL;KIF5B;CXCL8;...
ECM-receptor interaction 1.90 4.40e-3 80/88 (90.91%) ITGA6;ITGA3;ITGA5;...
Hypertrophic cardiomyopathy 1.87 7.54e-3 81/90 (90%) TPM1;ITGA6;ITGA3;...
Regulation of actin cytoskeleton 1.86 8.25e-3 185/218 (84.86%) ITGA6;ACTN1;ACTN4;...
Dilated cardiomyopathy 1.80 1.32e-2 86/96 (89.58%) TPM1;ITGA6;ITGA3;...
Proteoglycans in cancer 1.77 2.24e-2 172/205 (83.9%) CAV1;ITGA5;PXN;...
Renal cell carcinoma 1.74 3.36e-2 68/69 (98.55%) TGFB1;CDKN1A;AKT1;...
Colorectal cancer 1.72 3.85e-2 84/86 (97.67%) TGFB1;AREG;CDKN1A;...
Shigellosis 1.71 3.86e-2 180/246 (73.17%) ACTN1;ACTN4;ITGA5;...
Mineral absorption 1.70 3.87e-2 48/60 (80%) MT1E;MT1H;MT1HL1;...
Arrhythmogenic right ventricular cardiomyopathy 1.70 3.61e-2 70/77 (90.91%) ITGA6;ITGA3;ITGA5;...
NF-kappa B signaling pathway 1.70 3.38e-2 90/104 (86.54%) CXCL2;CXCL3;RELB;...
Small cell lung cancer 1.70 3.42e-2 90/92 (97.83%) ITGA6;ITGA3;COL4A5;...
Tryptophan metabolism -1.60 2.99e-2 35/42 (83.33%) ECHS1;KYAT1;GCDH;...
Nitrogen metabolism -1.61 2.94e-2 16/17 (94.12%) CA5B;CA3;CA14;...
Tyrosine metabolism -1.61 2.83e-2 30/36 (83.33%) ADH6;HPD;ADH1B;...
Nucleotide excision repair -1.62 2.55e-2 40/47 (85.11%) POLD3;CUL4B;LIG1;...
Proximal tubule bicarbonate reclamation -1.65 1.96e-2 21/23 (91.3%) GLUD1;ATP1B2;GLUD2;...
Sulfur metabolism -1.65 1.98e-2 9/10 (90%) PAPSS2;MPST;TST;...
Base excision repair -1.70 1.45e-2 29/33 (87.88%) NEIL3;APEX1;POLD3;...
Protein processing in endoplasmic reticulum -1.72 1.13e-2 127/171 (74.27%) RPN1;EIF2AK2;ATF4;...
beta-Alanine metabolism -1.73 1.04e-2 25/30 (83.33%) GAD2;DPYD;ALDH9A1;...
One carbon pool by folate -1.75 8.81e-3 15/20 (75%) SHMT2;MTHFS;ALDH1L1;...
Folate biosynthesis -1.76 8.14e-3 23/26 (88.46%) GGH;AKR1B1;PAH;...
Primary bile acid biosynthesis -1.78 6.62e-3 15/17 (88.24%) AKR1C4;SLC27A5;CYP7B1;...
Fanconi anemia pathway -1.79 6.17e-3 36/54 (66.67%) BRIP1;FANCA;PALB2;...
Ribosome -1.80 5.23e-3 113/158 (71.52%) RPS18;RPS10;RPL23A;...
Fatty acid degradation -1.83 4.16e-3 40/43 (93.02%) ACADS;ACSL4;ADH6;...
Arachidonic acid metabolism -1.85 1.97e-3 48/61 (78.69%) CYP2C9;CYP2J2;PLA2G6;...
Peroxisome -1.85 2.12e-3 72/82 (87.8%) SOD1;PIPOX;PEX12;...
Glycolysis / Gluconeogenesis -1.86 2.28e-3 56/67 (83.58%) PDHA1;PFKL;LDHB;...
Pyruvate metabolism -1.86 2.47e-3 41/47 (87.23%) ACACB;ADH6;DLD;...
Glutathione metabolism -1.89 1.35e-3 43/57 (75.44%) GSTK1;GSTA3;CHAC1;...
Histidine metabolism -1.90 1.48e-3 16/22 (72.73%) ALDH9A1;MAOB;ASPA;...
Ascorbate and aldarate metabolism -1.96 0.00e+0 15/30 (50%) UGDH;UGT2A3;RGN;...
Pentose and glucuronate interconversions -1.97 0.00e+0 17/34 (50%) UGDH;UGT2A3;GUSB;...
Glyoxylate and dicarboxylate metabolism -1.97 0.00e+0 23/30 (76.67%) GLDC;ACO2;SHMT2;...
Glycine, serine and threonine metabolism -1.98 0.00e+0 31/40 (77.5%) MAOA;PIPOX;SRR;...
Steroid hormone biosynthesis -1.98 0.00e+0 43/61 (70.49%) SULT1E1;CYP11A1;HSD11B1;...
Drug metabolism -2.00 0.00e+0 78/151 (51.66%) GSTM1;ADH6;UGT2A3;...
Mismatch repair -2.12 0.00e+0 22/23 (95.65%) POLD3;LIG1;MSH2;...
Metabolism of xenobiotics by cytochrome P450 -2.39 0.00e+0 49/77 (63.64%) GSTM2;GSTM1;ADH6;...
DNA replication -2.58 0.00e+0 34/36 (94.44%) RNASEH2A;POLD3;MCM7;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.04uM - 10uM 24H