Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMF1P6W)

Drug Name
SU 6656 Drug Info
Synonyms
su6656; 330161-87-0; SU-6656; SU6656; CHEMBL605003; (3z)-N,N-Dimethyl-2-Oxo-3-(4,5,6,7-Tetrahydro-1h-Indol-2-Ylmethylidene)-2,3-Dihydro-1h-Indole-5-Sulfonamide; (3Z)-N,N-dimethyl-2-oxo-3-(4,5,6,7-tetrahydro-1H-indol-2-ylmethylidene)-1H-indole-5-sulfonamide; SR-01000076237; 2,3-Dihydro-N,N-dimethyl-2-oxo-3-[(4,5,6,7-tetrahydro-1H-indol-2-yl)methylene]-1H-indole-5-sulfonamide; AC1NSM2X; Lopac-S-9692; Lopac0_000979; MLS002153475; GTPL6044; EX-A584; MolPort-003-959-609; HMS3229I04; HMS2232C04
Cross-matching ID
PubChem CID
5312137
ChEBI ID
CHEMBL605003
TTD Drug ID
D0CE3R

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Viral myocarditis 1.88 2.18e-2 53/60 (88.33%) CD40;DMD;CXADR;...
Autoimmune thyroid disease 1.87 1.46e-2 46/53 (86.79%) CD40;HLA-DOB;HLA-DPA1;...
Protein export 1.86 9.71e-3 17/23 (73.91%) SEC63;SEC62;SRP72;...
Mineral absorption 1.79 2.00e-2 48/60 (80%) MT1F;MT1H;MT2A;...
Allograft rejection 1.79 1.75e-2 32/38 (84.21%) CD40;HLA-DOB;HLA-DPA1;...
Protein digestion and absorption 1.77 1.94e-2 78/103 (75.73%) COL1A2;COL3A1;COL18A1;...
Cell adhesion molecules 1.68 4.79e-2 118/148 (79.73%) CDH5;ITGA6;NLGN4X;...
B cell receptor signaling pathway -1.66 4.61e-2 71/81 (87.65%) CD22;BTK;PIK3CA;...
Hepatitis C -1.66 4.85e-2 139/157 (88.54%) CASP9;MAVS;PIK3CA;...
Shigellosis -1.67 4.83e-2 180/246 (73.17%) NLRP3;ATG5;NFKB1;...
Phagosome -1.68 4.50e-2 118/152 (77.63%) FCGR2C;ATP6V1A;ATP6V0A1;...
Neutrophil extracellular trap formation -1.69 4.22e-2 101/189 (53.44%) CLEC7A;AZU1;FPR3;...
mTOR signaling pathway -1.71 3.63e-2 114/154 (74.03%) MAP2K1;TNF;CLIP1;...
Autophagy -1.71 3.61e-2 113/169 (66.86%) ATG7;SUPT20H;ATG5;...
NOD-like receptor signaling pathway -1.73 2.99e-2 145/181 (80.11%) NLRP3;ATG5;NFKB1;...
Influenza A -1.75 2.49e-2 156/172 (90.7%) TMPRSS11D;EIF2S1;MX2;...
Lipid and atherosclerosis -1.77 2.36e-2 190/215 (88.37%) PPP3CA;IRAK4;HSPD1;...
Measles -1.77 2.59e-2 133/139 (95.68%) EIF3H;RAB9A;CDK2;...
Legionellosis -1.79 2.31e-2 51/57 (89.47%) NAIP;CR1;SAR1B;...
Epithelial cell signaling in Helicobacter pylori infect... -1.80 2.43e-2 62/70 (88.57%) ATP6V1E1;CXCR2;SRC;...
Steroid biosynthesis -1.82 2.41e-2 19/20 (95%) NSDHL;EBP;DHCR7;...
ErbB signaling pathway -1.88 8.65e-3 79/85 (92.94%) CAMK2A;GRB2;SOS2;...
Hepatitis B -1.90 1.04e-2 151/162 (93.21%) IRAK4;IRF3;SMAD4;...
Rheumatoid arthritis -1.93 6.49e-3 78/93 (83.87%) ATP6V1E1;TGFB3;ATP6V1C1;...
Synaptic vesicle cycle -1.93 8.65e-3 63/78 (80.77%) ATP6V1F;CLTC;STX1A;...
Sulfur metabolism -2.01 6.49e-3 9/10 (90%) MPST;SQOR;TST;...
Collecting duct acid secretion -2.13 0.00e+0 22/27 (81.48%) ATP6V1E1;ATP6V1C1;ATP6V1B2;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Lung
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H