Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMF54ZG)

• Drug Name: Sulpiride Drug Info
• Synonyms: Abilit; Aiglonyl; Alimoral; Arminol; Calmoflorine; Championyl; Coolspan; Darleton; Deponerton; Desisulpid; Desmenat; Digton; Dobren; Dogmatil; Dogmatyl; Dolmatil; Dresent; Eglonil; Eglonyl; Ekilid; Enimon; Equilid; Eusulpid; Fardalan; Fidelan; Guastil; Isnamide; Kylistro; Lebopride; Levobren; Levopraid; Levosulpirida; Levosulpiridum; Lisopiride; Mariastel; Meresa; Miradol; Mirbanil; Misulvan; Neogama; Norestran; Normum; Nufarol; Omiryl; Omperan; Ozoderpin; Pontiride; Psicocen; Pyrikappl; Pyrkappl; Restful; Sernevin; Splotin; Stamonevrol; Sulp; Sulperide; Sulpirid; Sulpirida; Sulpiridum; Sulpitil; Sulpivert; Sulpor; Sulpride; Sulpyrid; Suprium; Sursumid; Synedil; Tepavil; Valirem; Zemorcon; Allphar Brand of Sulpiride; Almirall Brand of Sulpiride; Areu Brand of Sulpiride; Centrum Brand of Sulpiride; Desitin Brand of Sulpiride; Dolorgiet Brand of Sulpiride; Erempharma Brand of Sulpiride; Fumouzer Brand of Sulpiride; Hennig Brand of Sulpiride; Hexal Brand of Sulpiride; Hoechst Brand of Sulpiride; Hormosan Brand of Sulpiride; Krewel Brand of Sulpiride; Levosulpiride [INN]; Magnetic resonance imaging sulpiride; Pharmacia Brand of Sulpiride; Psicofarma Brand of Sulpiride; Rosemont Brand of Sulpiride; Sanofi Synthelabo Brand of Sulpiride; Spyfarma Brand of Sulpiride; Uriach Brand of Sulpiride; Vertigo Meresa; Vertigo neogama; RD 1403; S 8010; Bosnyl (TN); Dogmatil (TN); Dogmatyl (TN); Eglonyl (TN); Levosulpirida [INN-Spanish]; Levosulpiridum [INN-Latin]; Meresa (TN); Neuraxpharm (TN); RV-12309; Ratiopharm (TN); Sanofi-Synthelabo Brand of Sulpiride; Sulpirid (TN); Sulpirida [INN-Spanish]; Sulpiridum [INN-Latin]; Sulpiryd (TN); Vertigo-Meresa; Vertigo-neogama; R. D. 1403; R.D. 1403; Sulpiride (JP15/USAN/INN); Sulpiride [USAN:INN:BAN:JAN]; N-((1-Ethyl-2-pyrrolidinyl)methyl)-5-sulfamoyl-o-anisamide; (+/-)-Sulpiride; (RS)-(+/-)-sulpiride; (inverted question mark)-Sulpiride
• Therapeutic Class: Antipsychotic Agents
• Cross-matching ID:
  PubChem CID: 5355
  ChEBI ID: CHEMBL26
  CAS Number: CAS 15676-16-1
  TTD Drug ID: D03QGM
  VARIDT Drug ID: DR01168

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Proteasome	2.21	0.00e+0	44/46 (95.65%)	PSME2;PSMA3;PSMA2;...
DNA replication	2.11	0.00e+0	34/36 (94.44%)	PCNA;POLE2;MCM2;...
Oxidative phosphorylation	1.89	1.59e-2	93/133 (69.92%)	SDHD;ATP6V1D;NDUFA4;...
Glycine, serine and threonine metabolism	1.86	2.14e-2	31/40 (77.5%)	DLD;MAOA;GATM;...
Hematopoietic cell lineage	1.85	1.71e-2	90/99 (90.91%)	TFRC;ITGA4;ANPEP;...
Citrate cycle (TCA cycle)	1.84	1.59e-2	30/30 (100%)	DLD;SDHD;SUCLA2;...
Parkinson disease	1.78	3.13e-2	176/249 (70.68%)	MAOA;SDHD;PSMA3;...
Renal cell carcinoma	1.77	2.98e-2	68/69 (98.55%)	VEGFA;ARNT2;EGLN3;...
Prion disease	1.76	2.75e-2	209/273 (76.56%)	SDHD;PSMA3;PSMA2;...
Nucleotide excision repair	1.73	3.05e-2	40/47 (85.11%)	PCNA;POLE2;RBX1;...
Histidine metabolism	1.71	3.64e-2	16/22 (72.73%)	MAOA;ASPA;ALDH3A2;...
Ribosome	1.71	3.41e-2	113/158 (71.52%)	MRPL13;MRPL15;MRPL35;...
Tryptophan metabolism	1.71	3.15e-2	35/42 (83.33%)	DLD;IDO1;MAOA;...
Mismatch repair	1.70	3.06e-2	22/23 (95.65%)	PCNA;RFC4;RPA3;...
Nitrogen metabolism	1.68	3.68e-2	16/17 (94.12%)	CA2;CA12;CA4;...
Diabetic cardiomyopathy	1.67	3.93e-2	162/203 (79.8%)	SDHD;COL1A2;NOS3;...
Collecting duct acid secretion	1.66	4.09e-2	22/27 (81.48%)	CA2;SLC4A1;ATP6V1D;...
Glyoxylate and dicarboxylate metabolism	1.65	4.50e-2	23/30 (76.67%)	DLD;ACAT2;GLDC;...
Proximal tubule bicarbonate reclamation	1.64	4.46e-2	21/23 (91.3%)	CA2;FXYD2;CA4;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone

Osteosarcoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
U-2 OS	CVCL_0042	Homo sapiens	10uM	6H	Hide ▲

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	0.01uM - 10uM	6H, 24H	Hide ▲

Cervix

Cervical adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HeLa	CVCL_0030	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼

Hematopoietic system

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
ASC	CVCL_U602	Homo sapiens	10uM	24H	Show ▼

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼

Liver

Hepatoblastoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Hep G2	CVCL_0027	Homo sapiens	10uM	6H	Show ▼

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	10uM	6H, 24H	Show ▼

Non-small cell lung carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HCC515	CVCL_5134	Homo sapiens	10uM	6H, 24H	Show ▼

Pancreas

Pancreatic carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
YAPC	CVCL_1791	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼
VCaP	CVCL_2235	Homo sapiens	10uM	6H, 24H	Show ▼

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼