Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMF5GZI)

Drug Name
RG7388 Drug Info
Synonyms
Idasanutlin; RG7388; 1229705-06-9; Idasanutlin (RG-7388); RG-7388; UNII-QSQ883V35U; QSQ883V35U; CHEMBL2402737; Benzoic acid, 4-((((2R,3S,4R,5S)-3-(3-chloro-2-fluorophenyl)-4-(4-chloro-2-fluorophenyl)-4-cyano-5-(2,2-dimethylpropyl)-2-pyrrolidinyl)carbonyl)amino)-3-methoxy-; RO5503781; Idasanutlin [USAN:INN]; Benzoic acid, 4-[[[(2R,3S,4R,5S)-3-(3-chloro-2-fluorophenyl)-4-(4-chloro-2-fluorophenyl)-4-cyano-5-(2,2-dimethylpropyl)-2-pyrrolidinyl]carbonyl]amino]-3-methoxy-; RG-7388;Idasanutlin; RO-5503781; SCHEMBL442856
Cross-matching ID
PubChem CID
53358942
ChEBI ID
CHEMBL2402737
CAS Number
CAS 1229705-06-9
TTD Drug ID
D0OC4O

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Oxidative phosphorylation 2.04 1.25e-2 93/133 (69.92%) ATP5MG;ATP5PD;COX7C;...
Parkinson disease 1.98 1.25e-2 176/249 (70.68%) CALML3;SLC25A6;BAX;...
p53 signaling pathway 1.89 1.66e-2 63/73 (86.3%) CDKN1A;SESN1;DDB2;...
Basal transcription factors -1.67 3.10e-2 37/45 (82.22%) GTF2H3;GTF2I;TBP;...
RNA transport -1.72 2.16e-2 128/186 (68.82%) NUP214;XPO1;NUP43;...
Systemic lupus erythematosus -1.80 1.01e-2 45/135 (33.33%) FCGR3B;ELANE;SNRPD1;...
Oocyte meiosis -1.81 1.04e-2 90/129 (69.77%) PPP1CC;PKMYT1;FBXO5;...
mRNA surveillance pathway -1.88 6.08e-3 71/98 (72.45%) SAP18;PPP2R5A;PABPC1;...
Terpenoid backbone biosynthesis -1.88 6.76e-3 18/22 (81.82%) ICMT;DHDDS;MVD;...
Steroid biosynthesis -1.90 6.65e-3 19/20 (95%) EBP;CYP24A1;HSD17B7;...
Progesterone-mediated oocyte maturation -1.93 4.35e-3 75/100 (75%) RAF1;PKMYT1;CDC25C;...
Fanconi anemia pathway -1.95 2.53e-3 36/54 (66.67%) FANCE;FANCL;RAD51C;...
Spliceosome -2.00 1.52e-3 101/150 (67.33%) HNRNPA1;SF3B3;SRSF4;...
Homologous recombination -2.10 1.90e-3 35/41 (85.37%) TOPBP1;SSBP1;RAD51C;...
Mismatch repair -2.12 2.53e-3 22/23 (95.65%) RFC1;RPA3;RPA2;...
DNA replication -2.30 0.00e+0 34/36 (94.44%) POLA1;RPA2;PRIM2;...
Cell cycle -2.35 0.00e+0 110/124 (88.71%) CDK2;CDK6;SMAD4;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H