Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMF9M57)

Drug Name
Cotellic Drug Info
Synonyms
Cobimetinib fumarate; Cobimetinib Fumarate; Cobimetinib hemifumarate; Xl-518 hemifumarate; GDC-0973 hemifumarate; UNII-6EXI96H8SV; 6EXI96H8SV; Cobimetinib fumarate [USAN]; 1369665-02-0; Cobimetinib fumarate (USAN); Cotellic (TN); CHEMBL2364607; CHEBI:90853; Methanone, (3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)phenyl)(3-hydroxy-3-(2S)-2-piperidinyl-1-azetidinyl)-, (2E)-2-butenedioate (2:1); D10615; bis[(2S)-2-{1-[3,4-difluoro-2-(2-fluoro-4-iodoanilino)benzoyl]-3-hydroxyazetidin-3-yl}piperidin-1-ium] (2E)-but-2-enedioate
Cross-matching ID
PubChem CID
16222096
ChEBI ID
CHEMBL2146883
CAS Number
CAS 934660-93-2
TTD Drug ID
D0FJ9I

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Oxidative phosphorylation 2.69 0.00e+0 93/133 (69.92%) COX5B;ATP6V0E1;COX7B;...
Metabolism of xenobiotics by cytochrome P450 2.17 0.00e+0 49/77 (63.64%) MGST3;AKR1C1;GSTT1;...
Valine, leucine and isoleucine degradation 2.16 0.00e+0 42/48 (87.5%) HMGCS1;ALDH2;ALDH3A2;...
Fatty acid degradation 2.06 0.00e+0 40/43 (93.02%) CPT1A;ALDH2;ECI1;...
Butanoate metabolism 2.04 0.00e+0 23/28 (82.14%) BDH2;HMGCS1;HMGCL;...
Lysosome 1.98 0.00e+0 115/128 (89.84%) TPP1;CTSA;NEU1;...
Steroid hormone biosynthesis 1.96 0.00e+0 43/61 (70.49%) AKR1C3;AKR1C1;AKR1C2;...
Steroid biosynthesis 1.95 0.00e+0 19/20 (95%) MSMO1;LIPA;FDFT1;...
Tryptophan metabolism 1.90 3.06e-3 35/42 (83.33%) CAT;CYP1B1;ALDH2;...
Peroxisome 1.90 3.67e-3 72/82 (87.8%) ECH1;CAT;IDH1;...
Porphyrin and chlorophyll metabolism 1.87 4.18e-3 23/43 (53.49%) BLVRB;HMOX1;HEPH;...
Thermogenesis 1.84 5.36e-3 173/232 (74.57%) COX5B;ADCY9;COX7B;...
Diabetic cardiomyopathy 1.83 5.65e-3 162/203 (79.8%) COX5B;COX7B;SLC2A1;...
Other glycan degradation 1.83 5.25e-3 13/18 (72.22%) NEU1;HEXA;GLB1;...
Histidine metabolism 1.82 4.90e-3 16/22 (72.73%) ALDH2;ALDH3A2;CNDP2;...
Synthesis and degradation of ketone bodies 1.82 4.59e-3 9/10 (90%) BDH2;HMGCS1;HMGCL;...
Ascorbate and aldarate metabolism 1.77 8.65e-3 15/30 (50%) ALDH2;ALDH3A2;UGT2B17;...
ABC transporters 1.76 1.07e-2 37/45 (82.22%) ABCB6;TAP1;ABCG1;...
Collecting duct acid secretion 1.73 1.35e-2 22/27 (81.48%) ATP6V0E1;ATP6V1A;ATP6V1F;...
alpha-Linolenic acid metabolism 1.72 1.56e-2 17/25 (68%) FADS2;PLA2G4C;ACAA1;...
Ether lipid metabolism 1.71 1.75e-2 32/49 (65.31%) PLD3;GDPD3;PLA2G4C;...
Cardiac muscle contraction 1.70 1.67e-2 64/87 (73.56%) COX5B;TNNC1;COX7B;...
Terpenoid backbone biosynthesis 1.69 2.00e-2 18/22 (81.82%) HMGCS1;GGPS1;HMGCR;...
TNF signaling pathway -1.65 4.59e-2 103/112 (91.96%) MAPK10;CHUK;CREB3L1;...
Progesterone-mediated oocyte maturation -1.66 4.76e-2 75/100 (75%) AKT1;MAPK9;CCNA1;...
One carbon pool by folate -1.85 6.62e-3 15/20 (75%) SHMT2;MTHFD2L;GART;...
RNA polymerase -1.91 4.48e-3 23/31 (74.19%) POLR2E;POLR2H;POLR3F;...
Cell cycle -2.00 1.96e-3 110/124 (88.71%) CDC14B;PLK1;CDK6;...
Pyrimidine metabolism -2.00 2.15e-3 40/56 (71.43%) DUT;DCTPP1;DTYMK;...
Nucleotide excision repair -2.00 2.39e-3 40/47 (85.11%) GTF2H4;ERCC2;CCNH;...
Fanconi anemia pathway -2.05 1.34e-3 36/54 (66.67%) BRCA2;TELO2;FANCC;...
IL-17 signaling pathway -2.13 1.54e-3 84/94 (89.36%) MAPK10;CHUK;MMP1;...
Ribosome biogenesis in eukaryotes -2.15 1.79e-3 52/108 (48.15%) EIF6;MPHOSPH10;CSNK2A2;...
Base excision repair -2.21 0.00e+0 29/33 (87.88%) NEIL3;POLE3;PARP1;...
RNA transport -2.22 0.00e+0 128/186 (68.82%) NXF1;EIF2B2;EIF2B1;...
Mismatch repair -2.26 0.00e+0 22/23 (95.65%) RPA1;RPA2;POLD1;...
Spliceosome -2.49 0.00e+0 101/150 (67.33%) HSPA8;TRA2A;PCBP1;...
DNA replication -2.66 0.00e+0 34/36 (94.44%) RPA1;POLA2;POLA1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 0.12uM - 10uM 6H, 24H, 48H
Bone marrow
Chronic myeloid leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
K-562 CVCL_0004 Homo sapiens 0.01uM - 10uM 4H, 24H
Multiple myeloma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
KMS-34 CVCL_1333 Homo sapiens 0.01uM - 10uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 6H, 24H, 48H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 6H, 24H, 48H
Lymph node
Burkitt lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BJAB CVCL_5711 Homo sapiens 0.01uM - 10uM 4H
Diffuse large B-cell lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HBL-1 CVCL_4213 Homo sapiens 0.01uM - 10uM 4H, 24H
OCI-Ly10 CVCL_8795 Homo sapiens 0.01uM - 10uM 24H
OCI-Ly19 CVCL_8797 Homo sapiens 0.01uM - 10uM 4H, 24H
OCI-Ly3 CVCL_8796 Homo sapiens 0.01uM - 10uM 4H, 24H
TMD8 CVCL_A440 Homo sapiens 0.01uM - 10uM 4H, 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute B-lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NALM-6 CVCL_0092 Homo sapiens 0.01uM - 10uM 24H
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 4H, 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.04uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H
SK-MEL-5 CVCL_0527 Homo sapiens 0.01uM - 10uM 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.01uM - 2.22uM 24H