Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMFA5MY)

• Drug Name: Metoclopramide Drug Info
• Synonyms: Cerucal; Clopra; Clopromate; Duraclamid; Elieten; Emetid; Emitasol; Emperal; Eucil; Gastrese; Gastrobid; Gastromax; Gastronerton; Gastrosil; Gastrotablinen; Gastrotem; Imperan; Maxeran; Maxolon; Meclopran; Metaclopramide; Metaclopromide; Metamide; Methochlopramide; Methoclopramide; Metochlopramide; Metoclol; Metoclopramida; Metoclopramidum; Metocobil; Metramid; Moriperan; Mygdalon; Octamide; Parmid; Paspertin; Peraprin; Plasil; Pramidin; Pramiel; Pramin; Primperan; Reclomide; Reglan; Reliveran; Terperan; Metoclopramide Omega; DEL 1267; Apo-Metoclop; CLOPRA-YELLOW; Clopra-Yellow; Degan (TN); Elieten (TN); Gastro-Timelets; Maxeran (TN); Maxolon (TN); Metoclopramida [INN-Spanish]; Metoclopramide Monohydrochloride, Monohydrate; Metoclopramidum [INN-Latin]; Neu-Sensamide; Nu-Metoclopramide; Plasil (pharmaceutical); Pms-Metoclopramide; Primperan (TN); Pylomid (TN); Reglan (TN); Terperan (TN); Metoclopramide (JP15/INN); Metoclopramide [INN:BAN:JAN]; N-(Diethylaminoethyl)-2-methoxy-4-amino-5-chlorobenzamide; O-Anisamide, 4-amino-5-chloro-N-(2-(diethylamino)ethyl)-(8CI); Benzamide, 4-amino-5-chloro-N-(2-(diethylamino)ethyl)-2-methoxy-(9CI); (metaclopramide)4-Amino-5-chloro-N-(2-diethylamino-ethyl)-2-methoxy-benzamide; (metoclopramide)4-Amino-5-chloro-N-(2-diethylamino-ethyl)-2-methoxy-benzamide; 1,5-Dimethyl-2-phenyl-1,2-dihydro-pyrazol-3-one; 2-Methoxy-4-amino-5-chloro-N,N-dimethylaminoethyl)benzamide; 2-Methoxy-5-chloroprocainamide; 2-methoxy-4-amino-5-chloro-N,N-(dimethylaminoethyl)benzamide; 4 Amino-5-chloro-N-(2-(diethylamino)ethyl)-2-methoxybenzamide; 4-Amino-5-chloro-2-methoxy-N-(beta-diethylaminoethyl)benzamide; 4-Amino-5-chloro-N-(2-(diethylamino)ethyl)-2-methoxybenzamide; 4-Amino-5-chloro-N-(2-(diethylamino)ethyl)-o-anisamide; 4-Amino-5-chloro-N-(2-diethylamino-ethyl)-2-methoxy-benzamide; 4-Amino-5-chloro-N-(2-diethylamino-ethyl)-2-methoxy-benzamide (Mcp); 4-Amino-5-chloro-N-(2-diethylamino-ethyl)-2-methoxy-benzamide (metoclopramide); 4-Amino-5-chloro-N-(2-diethylamino-ethyl)-2-methoxy-benzamide(Metoclopramide); 4-amino-5-chloro-N-(2-diethylaminoethyl)-2-methoxybenzamide; 4-amino-5-chloro-N-[2-(diethylamino)ethyl]-2-methoxybenzamide; 5-Chloro-2-methoxyprocainamide
• Therapeutic Class: Antiemetics
• Cross-matching ID:
  PubChem CID: 4168
  ChEBI ID: CHEMBL86
  CAS Number: CAS 364-62-5
  TTD Drug ID: D08VYV
  VARIDT Drug ID: DR00840
  INTEDE Drug ID: DR1068
  ACDINA Drug ID: D00422

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Hedgehog signaling pathway	1.97	1.38e-2	43/56 (76.79%)	PRKACB;CCND2;SMURF2;...
Allograft rejection	1.92	6.89e-3	32/38 (84.21%)	HLA-DRA;HLA-DRB1;HLA-DPA1;...
Systemic lupus erythematosus	1.90	9.18e-3	45/135 (33.33%)	ACTN1;HLA-DRA;HLA-DRB1;...
Human T-cell leukemia virus 1 infection	1.87	2.07e-2	197/219 (89.95%)	PRKACB;HLA-DRA;HLA-DRB1;...
Type I diabetes mellitus	1.85	2.48e-2	38/43 (88.37%)	HLA-DRA;HLA-DRB1;HLA-DPA1;...
GnRH secretion	1.82	2.76e-2	60/64 (93.75%)	KRAS;GABBR1;PRKCB;...
Asthma	1.81	2.76e-2	25/31 (80.65%)	HLA-DRA;HLA-DRB1;HLA-DPA1;...
Viral carcinogenesis	1.79	2.41e-2	149/203 (73.4%)	ACTN1;PRKACB;CCND2;...
Dilated cardiomyopathy	1.77	2.76e-2	86/96 (89.58%)	PRKACB;DES;GNAS;...
Inflammatory bowel disease	1.75	3.31e-2	58/65 (89.23%)	TLR4;HLA-DRA;HLA-DRB1;...
Fc epsilon RI signaling pathway	1.74	3.38e-2	57/68 (83.82%)	KRAS;ALOX5AP;PIK3R1;...
Hepatitis B	1.72	3.56e-2	151/162 (93.21%)	TLR4;CYCS;KRAS;...
Osteoclast differentiation	1.72	3.39e-2	117/127 (92.13%)	ACP5;CREB1;IL1R1;...
B cell receptor signaling pathway	1.71	3.64e-2	71/81 (87.65%)	KRAS;PRKCB;NFKB1;...
Steroid biosynthesis	1.70	3.67e-2	19/20 (95%)	SOAT1;TM7SF2;SQLE;...
Neutrophil extracellular trap formation	1.69	3.87e-2	101/189 (53.44%)	TLR4;ITGAM;ELANE;...
Graft-versus-host disease	1.68	3.73e-2	32/42 (76.19%)	HLA-DRA;HLA-DRB1;HLA-DPA1;...
Th17 cell differentiation	1.68	3.52e-2	95/107 (88.79%)	HLA-DRA;HLA-DRB1;HLA-DPA1;...
Leishmaniasis	1.68	3.41e-2	67/77 (87.01%)	TLR4;HLA-DRA;HLA-DRB1;...
One carbon pool by folate	1.68	3.24e-2	15/20 (75%)	TYMS;AMT;FTCD;...
Glycolysis / Gluconeogenesis	1.65	4.46e-2	56/67 (83.58%)	PFKL;ALDH3A2;PGAM1;...
Yersinia infection	1.64	4.45e-2	120/137 (87.59%)	TLR4;ROCK2;ACTR2;...
Th1 and Th2 cell differentiation	1.64	4.31e-2	80/92 (86.96%)	HLA-DRA;HLA-DRB1;HLA-DPA1;...
Porphyrin and chlorophyll metabolism	-1.77	3.74e-2	23/43 (53.49%)	UGT2B15;UGT2B4;COX15;...
Folate biosynthesis	-1.91	8.30e-3	23/26 (88.46%)	GGH;ALPG;PCBD1;...
Nitrogen metabolism	-1.92	1.25e-2	16/17 (94.12%)	CA12;CA4;GLUL;...
Ferroptosis	-2.28	0.00e+0	36/41 (87.8%)	PRNP;MAP1LC3C;SLC39A8;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone

Osteosarcoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
U-2 OS	CVCL_0042	Homo sapiens	10uM	6H	Hide ▲

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	0.01uM - 10uM	6H, 24H	Hide ▲
MDA-MB-231	CVCL_0062	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Breast epithelium

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF-10A	CVCL_0598	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Cervix

Cervical adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HeLa	CVCL_0030	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼

Hematopoietic system

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
ASC	CVCL_U602	Homo sapiens	10uM	24H	Show ▼

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼

Normal (Transformed)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HEK293	CVCL_0045	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Liver

Hepatoblastoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Hep G2	CVCL_0027	Homo sapiens	10uM	6H	Show ▼

Hepatocellular carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HuH-7	CVCL_0336	Homo sapiens	12uM	72H	Show ▼

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼

Non-small cell lung carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HCC515	CVCL_5134	Homo sapiens	10uM	6H, 24H	Show ▼

Pancreas

Pancreatic carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
YAPC	CVCL_1791	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Peripheral blood

Acute monocytic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
THP-1	CVCL_0006	Homo sapiens	0.01uM - 10uM	24H	Show ▼

T-cell acute lymphoblastic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Jurkat	CVCL_0367	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	0.04uM - 10uM	6H, 24H	Show ▼
VCaP	CVCL_2235	Homo sapiens	10uM	6H, 24H	Show ▼

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼