Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMFAOKP)

Drug Name
Fenoldopam Drug Info
Synonyms
Carlacor; Fenoldopamum; Fenodopam mesylate; Fenoldopamum [Latin]; SKF 82526; Carlacor (TN); Corlopam (TN); Fenoldopam (INN);Fenoldopam [INN:BAN]; SKF 82526-J; SKF-82526J; SK&F-82526; 6-chloro-1-(4-hydroxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol; 9-chloro-5-(4-hydroxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol
Therapeutic ClassAntihypertensive Agents
Cross-matching ID
PubChem CID
3341
ChEBI ID
CHEMBL588
CAS Number
CAS 67227-56-9
TTD Drug ID
D0R6BI

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
DNA replication 2.13 0.00e+0 34/36 (94.44%) RFC2;MCM3;RNASEH2A;...
Th1 and Th2 cell differentiation 2.07 5.35e-3 80/92 (86.96%) NFATC3;HLA-DRA;HLA-DPA1;...
Graft-versus-host disease 1.99 3.57e-3 32/42 (76.19%) HLA-DRA;HLA-DPA1;HLA-DRB1;...
Leishmaniasis 1.96 5.35e-3 67/77 (87.01%) HLA-DRA;HLA-DPA1;HLA-DRB1;...
Antigen processing and presentation 1.95 4.28e-3 60/78 (76.92%) CD74;HLA-DRA;HLA-DPA1;...
Type I diabetes mellitus 1.94 3.57e-3 38/43 (88.37%) HLA-DRA;HLA-DPA1;HLA-DRB1;...
Mismatch repair 1.92 4.59e-3 22/23 (95.65%) RFC2;RFC5;PCNA;...
Tuberculosis 1.88 4.01e-3 159/180 (88.33%) CD74;HLA-DRA;HLA-DPA1;...
Ribosome biogenesis in eukaryotes 1.82 1.43e-2 52/108 (48.15%) NOP56;NVL;NOL6;...
Herpes simplex virus 1 infection 1.79 1.93e-2 165/498 (33.13%) CD74;HLA-DRA;HLA-DPA1;...
Asthma 1.77 2.04e-2 25/31 (80.65%) HLA-DRA;HLA-DPA1;HLA-DRB1;...
Intestinal immune network for IgA production 1.77 1.96e-2 38/48 (79.17%) HLA-DRA;HLA-DPA1;HLA-DRB1;...
Autoimmune thyroid disease 1.75 2.06e-2 46/53 (86.79%) HLA-DRA;HLA-DPA1;HLA-DRB1;...
Hematopoietic cell lineage 1.73 1.99e-2 90/99 (90.91%) HLA-DRA;HLA-DPA1;HLA-DRB1;...
T cell receptor signaling pathway 1.70 2.50e-2 93/104 (89.42%) NFATC3;PIK3R3;LCP2;...
Allograft rejection 1.68 2.94e-2 32/38 (84.21%) HLA-DRA;HLA-DPA1;HLA-DRB1;...
Inflammatory bowel disease 1.67 3.02e-2 58/65 (89.23%) HLA-DRA;HLA-DPA1;HLA-DRB1;...
RNA transport 1.62 4.58e-2 128/186 (68.82%) EIF4G3;PNN;FUS;...
Parkinson disease -1.69 4.05e-2 176/249 (70.68%) PSMA2;BAX;PSMD8;...
Complement and coagulation cascades -1.71 3.43e-2 76/85 (89.41%) F13B;CFI;PROCR;...
Ascorbate and aldarate metabolism -1.71 3.68e-2 15/30 (50%) RGN;UGT2A3;ALDH2;...
Malaria -1.73 3.45e-2 44/50 (88%) CD36;SELE;SDC2;...
African trypanosomiasis -1.73 3.57e-2 32/37 (86.49%) PRKCB;PLCB3;KNG1;...
Primary bile acid biosynthesis -1.73 3.90e-2 15/17 (88.24%) CYP7B1;AMACR;SLC27A5;...
Ether lipid metabolism -1.75 3.43e-2 32/49 (65.31%) PLA2G10;PLPP2;LPCAT4;...
Nicotinate and nicotinamide metabolism -1.79 2.33e-2 25/35 (71.43%) NMNAT2;PNP;SIRT3;...
Drug metabolism -1.80 2.03e-2 78/151 (51.66%) ADH6;NAT1;CYP3A4;...
Retinol metabolism -1.80 2.31e-2 41/68 (60.29%) LRAT;ADH6;CYP3A4;...
Renin-angiotensin system -1.81 2.38e-2 20/23 (86.96%) CTSG;CTSA;ACE2;...
Oxidative phosphorylation -1.88 1.33e-2 93/133 (69.92%) TCIRG1;ATP6V0C;NDUFS7;...
Mineral absorption -1.96 0.00e+0 48/60 (80%) SLC34A2;ATP2B1;FTL;...
Metabolism of xenobiotics by cytochrome P450 -2.02 0.00e+0 49/77 (63.64%) GSTA1;GSTK1;GSTM5;...
Steroid hormone biosynthesis -2.05 0.00e+0 43/61 (70.49%) CYP3A4;CYP7B1;DHRS11;...
Pentose and glucuronate interconversions -2.06 0.00e+0 17/34 (50%) AKR1B10;UGDH;UGT2B4;...
×

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 6H, 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 2.22uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 2.22uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 6H, 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 2.22uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HuH-7 CVCL_0336 Homo sapiens 10uM 72H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 2.22uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 2.22uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 6H, 24H