Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMFBNA3)

Drug Name
Nicaraven Drug Info
Synonyms AVS; Antevan; Antevas
Cross-matching ID
PubChem CID
71234
CAS Number
CAS 79455-30-4
TTD Drug ID
D0Z2UW

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Tryptophan metabolism 1.99 1.31e-2 35/42 (83.33%) DLD;MAOB;TDO2;...
Ribosome biogenesis in eukaryotes 1.98 6.57e-3 52/108 (48.15%) NVL;HEATR1;NAT10;...
Cysteine and methionine metabolism 1.92 4.38e-3 43/50 (86%) BHMT2;LDHA;LDHB;...
One carbon pool by folate 1.85 9.85e-3 15/20 (75%) MTHFD1;ATIC;DHFR;...
Complement and coagulation cascades 1.85 7.88e-3 76/85 (89.41%) C3;C7;CFI;...
DNA replication 1.80 1.53e-2 34/36 (94.44%) DNA2;MCM4;MCM6;...
Glyoxylate and dicarboxylate metabolism 1.70 4.31e-2 23/30 (76.67%) DLD;GLDC;SHMT1;...
Valine, leucine and isoleucine degradation 1.69 4.60e-2 42/48 (87.5%) DLD;AOX1;ACAD8;...
Aminoacyl-tRNA biosynthesis 1.64 4.66e-2 15/66 (22.73%) DARS2;HARS2;NARS2;...
Propanoate metabolism 1.63 4.65e-2 30/34 (88.24%) DLD;LDHA;LDHB;...
Fatty acid degradation 1.61 5.00e-2 40/43 (93.02%) ADH5;ACSL1;ECHS1;...
TNF signaling pathway -1.92 3.86e-2 103/112 (91.96%) TRAF3;ATF4;RPS6KA5;...
Osteoclast differentiation -1.97 3.86e-2 117/127 (92.13%) MAP2K6;MAPK3;JAK1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.04uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.04uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.01uM - 10uM 24H