Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMFCLYW)

Drug Name
Moxisylyte Drug Info
Synonyms Thymoxamine
Cross-matching ID
PubChem CID
4260
ChEBI ID
CHEMBL159226
CAS Number
CAS 54-32-0
TTD Drug ID
D0A7QN

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Oxidative phosphorylation 2.38 0.00e+0 93/133 (69.92%) COX7B;ATP5F1E;SDHD;...
Ribosome 2.22 0.00e+0 113/158 (71.52%) MRPL15;MRPL13;MRPL16;...
DNA replication 2.02 2.29e-3 34/36 (94.44%) PCNA;POLD3;FEN1;...
Cell cycle 1.90 3.44e-3 110/124 (88.71%) CDC20;E2F2;CCNE2;...
Parkinson disease 1.78 2.75e-2 176/249 (70.68%) GNAS;COX7B;ATP5F1E;...
Mismatch repair 1.77 2.29e-2 22/23 (95.65%) PCNA;POLD3;RPA3;...
Basal transcription factors 1.76 2.06e-2 37/45 (82.22%) TBPL1;MNAT1;CCNH;...
Non-alcoholic fatty liver disease 1.76 1.81e-2 126/155 (81.29%) COX7B;SDHD;NDUFB1;...
Diabetic cardiomyopathy 1.73 2.83e-2 162/203 (79.8%) PLN;COX7B;ATP5F1E;...
Nucleotide excision repair 1.68 4.13e-2 40/47 (85.11%) PCNA;RAD23B;POLD3;...
Homologous recombination 1.68 3.75e-2 35/41 (85.37%) RAD51C;POLD3;BARD1;...
Collecting duct acid secretion 1.68 3.61e-2 22/27 (81.48%) SLC4A1;ATP6V1B1;ATP6V1D;...
Thermogenesis 1.64 4.60e-2 173/232 (74.57%) GNAS;COX7B;ATP5F1E;...
Mineral absorption 1.61 4.95e-2 48/60 (80%) TF;MT1F;MT1E;...
PD-L1 expression and PD-1 checkpoint pathway in cancer -1.66 4.83e-2 79/89 (88.76%) TLR4;PIK3CB;NFKBIE;...
Pentose phosphate pathway -1.75 1.88e-2 25/30 (83.33%) FBP2;PRPS1;TKTL1;...
Dilated cardiomyopathy -1.75 1.92e-2 86/96 (89.58%) ITGB4;SGCB;CACNG1;...
Type I diabetes mellitus -1.79 1.19e-2 38/43 (88.37%) HLA-DQB1;HLA-DPB1;TNF;...
Inflammatory bowel disease -1.80 1.00e-2 58/65 (89.23%) TLR4;IL18RAP;NFATC1;...
Allograft rejection -1.80 9.83e-3 32/38 (84.21%) HLA-DQB1;HLA-DPB1;TNF;...
Cell adhesion molecules -1.81 9.58e-3 118/148 (79.73%) ICOS;ITGAV;CDH2;...
NF-kappa B signaling pathway -1.82 6.97e-3 90/104 (86.54%) ERC1;IRAK1;LTBR;...
Th1 and Th2 cell differentiation -1.84 5.11e-3 80/92 (86.96%) CD4;STAT4;IL2RB;...
C-type lectin receptor signaling pathway -1.84 4.26e-3 93/104 (89.42%) CBLB;PIK3CB;EGR3;...
IL-17 signaling pathway -1.87 3.19e-3 84/94 (89.36%) TNF;MMP9;FOS;...
Hypertrophic cardiomyopathy -1.90 1.83e-3 81/90 (90%) ITGB4;SGCB;CACNG1;...
Graft-versus-host disease -1.92 0.00e+0 32/42 (76.19%) PRF1;KIR2DL1;HLA-DQB1;...
Intestinal immune network for IgA production -1.96 0.00e+0 38/48 (79.17%) LTBR;ICOS;HLA-DQB1;...
Hematopoietic cell lineage -1.97 0.00e+0 90/99 (90.91%) ITGA2B;HLA-DQB1;IL5RA;...
Arrhythmogenic right ventricular cardiomyopathy -2.06 0.00e+0 70/77 (90.91%) JUP;SGCG;CTNNA2;...
Rheumatoid arthritis -2.09 0.00e+0 78/93 (83.87%) TNF;HLA-DRB1;FOS;...
TNF signaling pathway -2.19 0.00e+0 103/112 (91.96%) VCAM1;TNF;MMP9;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 6H, 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
HEK293T CVCL_0063 Homo sapiens 0.125uM - 10uM 6H, 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.04uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 6H, 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.01uM - 10uM 24H