Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMFDC0Q)

• Drug Name: Tiotropium Drug Info
• Synonyms: 186691-13-4; UNII-0EB439235F; 0EB439235F; [3H]tiotropium; (1r,2r,4s,5s,7s)-7-{[hydroxy(Dithiophen-2-Yl)acetyl]oxy}-9,9-Dimethyl-3-Oxa-9-Azoniatricyclo[3310~2,4~]nonane; NCGC00167971-01; 0HK; (1R,2R,4S,5S)-7-{[2-hydroxy-2,2-bis(thiophen-2-yl)acetyl]oxy}-9,9-dimethyl-3-oxa-9-azatricyclo[3310^{2,4}]nonan-9-ium; GTPL367; SCHEMBL4662461; GTPL8592; DTXSID5044281; CHEMBL3305968; Spiriva (TN); Tiotropium bromide [USAN:INN]; (1A,2A,4A,5A,7A)-7-[(Hydroxydi-2-thienylacetyl)oxy]-9,9-dimethyl-3-oxa-9-azoniatri-cyclo[331024]nonane bromide; (1a,2,4,5a,7)-7-[(2-Hydroxy-2,2-di-2-thienylacetyl)oxy]-9,9-dimethyl-3-oxa-9-azoniatricyclo[33102,4]nonane bromide; 7-{[hydroxy(dithiophen-2-yl)acetyl]oxy}-9,9-dimethyl-3-oxa-9-azoniatricyclo[33102,4]nonane bromide
• Therapeutic Class: Bronchodilator Agents
• Cross-matching ID:
  PubChem CID: 5487427
  ChEBI ID: CHEMBL90960
  CAS Number: CAS 186691-13-4
  TTD Drug ID: D0P1WA
  VARIDT Drug ID: DR00017
  ACDINA Drug ID: D00681

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Protein export	1.96	0.00e+0	17/23 (73.91%)	OXA1L;SRPRA;SEC62;...
Aldosterone-regulated sodium reabsorption	-1.85	4.09e-2	34/37 (91.89%)	NEDD4L;FXYD2;PRKCB;...
Steroid biosynthesis	-1.90	3.12e-2	19/20 (95%)	MSMO1;FDFT1;EBP;...
PPAR signaling pathway	-1.94	2.92e-2	66/74 (89.19%)	FADS2;PPARA;ACSL4;...
Fatty acid elongation	-2.08	0.00e+0	19/27 (70.37%)	HADH;PPT1;ELOVL1;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Liver

Hepatocellular carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HuH-7	CVCL_0336	Homo sapiens	6.66uM	72H	Hide ▲