Details of the Drug Pharmacogenomic Perturbation Atlas

Avasimibe Drug Info

Avasimibe; 166518-60-1; CI-1011; Avasimibe(CI-1011); UNII-28LQ20T5RC; CI 1011; Avasimibe (CI-1011); PD 148515; CHEMBL101309; 28LQ20T5RC; 2,6-Diisopropylphenyl (2-(2,4,6-triisopropylphenyl)acetyl)sulfamate; 2,6-diisopropylphenyl 2-(2,4,6-triisopropylphenyl)acetylsulfamate; 2,6-Diisopropylphenyl ((2,4,6-triisopropylphenyl)acetyl)sulfamate; 2,6-Diisopropylphenyl (2-(2,4,6-triisopropylphenyl)-acetyl)sulfamate; ((2,4,6-Tris(1-methylethyl)phenyl)acetyl)sulfamic acid 2,6-bis(1-methylethyl)phenyl ester

Cross-matching ID

PubChem CID

166558

ChEBI ID

CHEMBL101309

CAS Number

CAS 166518-60-1

TTD Drug ID

D0O1KX

General Information of Drug (ID: DMFG4OM)

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Porphyrin and chlorophyll metabolism	1.92	4.98e-2	23/43 (53.49%)	UGT2B15;GUSB;CPOX;...
Cysteine and methionine metabolism	1.88	4.15e-2	43/50 (86%)	PSAT1;CTH;CBS;...
Arginine biosynthesis	1.79	4.78e-2	17/22 (77.27%)	ASS1;ARG1;GOT1;...
Glycine, serine and threonine metabolism	1.78	4.15e-2	31/40 (77.5%)	PSAT1;SHMT2;CTH;...
Linoleic acid metabolism	1.77	3.74e-2	21/29 (72.41%)	PLAAT3;PLA2G4A;CYP2J2;...
Alanine, aspartate and glutamate metabolism	1.75	4.04e-2	27/37 (72.97%)	ASNS;ASS1;GOT1;...
One carbon pool by folate	1.74	4.05e-2	15/20 (75%)	SHMT2;MTHFD2;MTHFD1;...
Protein export	1.72	4.71e-2	17/23 (73.91%)	OXA1L;SRPRB;HSPA5;...
Proximal tubule bicarbonate reclamation	1.71	4.57e-2	21/23 (91.3%)	CA2;PCK2;GLS2;...
Natural killer cell mediated cytotoxicity	-1.80	2.24e-2	99/131 (75.57%)	SYK;IFNB1;LCP2;...
IL-17 signaling pathway	-1.83	1.96e-2	84/94 (89.36%)	TNF;MAPK11;IL1B;...
Terpenoid backbone biosynthesis	-1.84	2.44e-2	18/22 (81.82%)	MVK;GGPS1;DHDDS;...
Osteoclast differentiation	-1.86	2.85e-2	117/127 (92.13%)	SYK;IFNB1;LCP2;...
Cholesterol metabolism	-1.97	0.00e+0	44/50 (88%)	CYP27A1;LRP1;NPC1;...
Steroid biosynthesis	-2.20	0.00e+0	19/20 (95%)	CYP51A1;DHCR7;DHCR24;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Breast adenocarcinoma

Breast epithelium

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF-10A	CVCL_0598	Homo sapiens	0.01uM - 10uM	24H

Cervix

Cervical adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HeLa	CVCL_0030	Homo sapiens	0.01uM - 10uM	24H

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	0.01uM - 10uM	24H

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	0.01uM - 10uM	24H

Normal (Transformed)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HEK293	CVCL_0045	Homo sapiens	0.01uM - 10uM	24H

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	0.01uM - 10uM	24H

Pancreas

Pancreatic carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
YAPC	CVCL_1791	Homo sapiens	0.01uM - 10uM	24H

Peripheral blood

Acute monocytic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
THP-1	CVCL_0006	Homo sapiens	0.01uM - 10uM	24H

T-cell acute lymphoblastic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Jurkat	CVCL_0367	Homo sapiens	0.01uM - 10uM	24H

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	0.01uM - 10uM	24H

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	0.01uM - 10uM	24H

Umbilical vein

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HUVEC-C	CVCL_2959	Homo sapiens	0.01uM - 2.22uM	24H