Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMFGLXB)

• Drug Name: Phensuximide Drug Info
• Synonyms: Phensuximide; Milontin; Succitimal; Lifene; Phenylsuximide; Epimid; Fensuccimide; Fenosuccimide; Phensuximidum; 86-34-0; phensuccimide; Fensuximida; Phensuximid; Methylphenylsuccinimide; Fensuccimide [DCIT]; Succinimide, N-methyl-2-phenyl-; Phensuximidum [INN-Latin]; Fensuximida [INN-Spanish]; 1-methyl-3-phenylpyrrolidine-2,5-dione; Mirontin; Milonton; N-Methyl-alpha-phenylsuccinimide; PM 334; N-Methyl-2-phenylsuccinimide; Milontin (TN); 1-Methyl-3-phenylpyrrolidin-2,5-dione; 1-Methyl-3-phenyl-2,5-pyrrolidinedione; EINECS 201-664-6
• Cross-matching ID:
  PubChem CID: 6839
  ChEBI ID: CHEMBL8079
  CAS Number: CAS 86-34-0
  TTD Drug ID: D06BYV

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Renin-angiotensin system	-1.84	3.47e-2	20/23 (86.96%)	MME;ACE2;AGTR2;...
ABC transporters	-1.89	1.95e-2	37/45 (82.22%)	DEFB1;ABCB9;ABCC2;...
Th1 and Th2 cell differentiation	-2.00	0.00e+0	80/92 (86.96%)	CD247;STAT1;HLA-DMB;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone

Osteosarcoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
U-2 OS	CVCL_0042	Homo sapiens	10uM	6H	Hide ▲

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	0.04uM - 10uM	6H, 24H	Hide ▲

Cervix

Cervical adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HeLa	CVCL_0030	Homo sapiens	0.01uM - 10uM	3H, 24H	Show ▼

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼

Non-small cell lung carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HCC515	CVCL_5134	Homo sapiens	10uM	6H	Show ▼

Pancreas

Pancreatic carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
YAPC	CVCL_1791	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼
VCaP	CVCL_2235	Homo sapiens	10uM	6H, 24H	Show ▼

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼