Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMFGOW0)

Drug Name
NAAG Drug Info
Synonyms N-acetylaspartylglutamate; spaglumic acid; isospaglumic acid
Cross-matching ID
PubChem CID
188803
ChEBI ID
CHEMBL73688
CAS Number
CAS 3106-85-2
TTD Drug ID
D02FCY
VARIDT Drug ID
DR01243

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Tyrosine metabolism -1.64 4.81e-2 30/36 (83.33%) ADH7;ADH1A;TPO;...
Pertussis -1.67 3.79e-2 64/76 (84.21%) C1QB;GNAI3;CD14;...
Leishmaniasis -1.67 3.92e-2 67/77 (87.01%) IFNGR1;JAK1;TGFB1;...
PPAR signaling pathway -1.68 3.55e-2 66/74 (89.19%) ACSL4;PCK1;PPARD;...
Cholesterol metabolism -1.70 2.89e-2 44/50 (88%) TSPO;ABCA1;ANGPTL3;...
Synthesis and degradation of ketone bodies -1.70 3.15e-2 9/10 (90%) ACAT2;HMGCS1;ACAT1;...
Metabolism of xenobiotics by cytochrome P450 -1.75 2.41e-2 49/77 (63.64%) ADH6;CYP3A4;CYP1B1;...
Glutathione metabolism -1.79 1.92e-2 43/57 (75.44%) GSR;GGT5;GSTM5;...
Arachidonic acid metabolism -1.83 1.32e-2 48/61 (78.69%) PTGS1;ALOX12;GGT5;...
Thyroid hormone synthesis -1.87 6.87e-3 66/75 (88%) ASGR2;CANX;TPO;...
Drug metabolism -1.90 4.81e-3 78/151 (51.66%) GSTM5;CES2;ADH7;...
Fructose and mannose metabolism -1.91 5.77e-3 30/33 (90.91%) HKDC1;ALDOA;PFKFB3;...
Staphylococcus aureus infection -1.98 2.41e-3 72/95 (75.79%) DEFA4;C1S;C5;...
Retinol metabolism -2.11 0.00e+0 41/68 (60.29%) CYP26B1;CYP3A7;CYP2C9;...
Fatty acid degradation -2.13 0.00e+0 40/43 (93.02%) ACADVL;ACADS;ALDH9A1;...
Complement and coagulation cascades -2.35 0.00e+0 76/85 (89.41%) C1S;C8A;C5;...
×

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H