Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMFGYKS)

Drug Name
MK-5108 Drug Info
Synonyms
1010085-13-8; VX-689; MK 5108; MK5108; MK-5108 (VX-689); UNII-H8J407531S; VX689; VX 689; CHEMBL3600873; H8J407531S; 4-(3-chloro-2-fluorophenoxy)-1-[[6-(1,3-thiazol-2-ylamino)pyridin-2-yl]methyl]cyclohexane-1-carboxylic acid; 4-(3-Chloranyl-2-Fluoranyl-Phenoxy)-1-[[6-(1,3-Thiazol-2-Ylamino)pyridin-2-Yl]methyl]cyclohexane-1-Carboxylic Acid; (1r,4r)-4-(3-chloro-2-fluorophenoxy)-1-((6-(thiazol-2-ylamino)pyridin-2-yl)methyl)cyclohexane-1-carboxylic acid; Cyclohexanecarboxylic acid,; MK-5108/VX-689
Cross-matching ID
PubChem CID
24748204
ChEBI ID
CHEMBL125340
CAS Number
CAS 1010085-13-8
TTD Drug ID
D0J6AB

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Phosphatidylinositol signaling system 2.06 0.00e+0 82/97 (84.54%) PRKCA;PIK3R1;PIK3CD;...
Small cell lung cancer 2.00 0.00e+0 90/92 (97.83%) BIRC3;LAMB1;PTGS2;...
Progesterone-mediated oocyte maturation 1.89 1.48e-2 75/100 (75%) AURKA;CCNB2;CCNB1;...
Carbohydrate digestion and absorption 1.88 1.66e-2 37/47 (78.72%) HK2;PIK3R1;PIK3CD;...
Proteasome 1.85 1.33e-2 44/46 (95.65%) PSMD4;PSMD1;PSMD12;...
Ribosome biogenesis in eukaryotes 1.84 1.11e-2 52/108 (48.15%) DROSHA;NOP56;NAT10;...
Cell cycle 1.77 3.01e-2 110/124 (88.71%) CDC20;CCNB2;CCNB1;...
Amoebiasis 1.76 3.05e-2 99/102 (97.06%) LAMB1;ACTN1;LAMC1;...
Bacterial invasion of epithelial cells 1.76 2.71e-2 59/77 (76.62%) CAV1;CAV2;ITGA5;...
Spliceosome 1.71 4.33e-2 101/150 (67.33%) HNRNPM;FUS;PRPF4;...
Primary immunodeficiency 1.71 4.24e-2 33/38 (86.84%) IL7R;TAP2;ICOS;...
Type I diabetes mellitus -1.64 4.40e-2 38/43 (88.37%) HLA-E;HLA-DPB1;HLA-DPA1;...
Pyruvate metabolism -1.65 4.58e-2 41/47 (87.23%) ACAT1;ADH5;HAGH;...
Folate biosynthesis -1.67 3.77e-2 23/26 (88.46%) ALPL;GGH;GCH1;...
Alcoholism -1.67 3.86e-2 86/186 (46.24%) CAMKK2;PPP1CC;HDAC2;...
Pantothenate and CoA biosynthesis -1.67 3.81e-2 14/21 (66.67%) PPCS;DPYS;ENPP1;...
PPAR signaling pathway -1.70 3.39e-2 66/74 (89.19%) ACSL4;ACADM;OLR1;...
Histidine metabolism -1.71 3.37e-2 16/22 (72.73%) FTCD;HNMT;MAOA;...
Drug metabolism -1.73 3.34e-2 78/151 (51.66%) CMPK1;CYP1A2;DPYS;...
Steroid biosynthesis -1.75 2.55e-2 19/20 (95%) DHCR7;FDFT1;DHCR24;...
Fatty acid degradation -1.76 2.82e-2 40/43 (93.02%) ACAA2;ACADS;ECI1;...
Thermogenesis -1.78 2.85e-2 173/232 (74.57%) COX6B1;COX16;ACTB;...
Steroid hormone biosynthesis -1.91 1.34e-2 43/61 (70.49%) HSD11B1;HSD17B12;CYP1A2;...
Metabolism of xenobiotics by cytochrome P450 -2.22 0.00e+0 49/77 (63.64%) HSD11B1;CYP1A2;UGT2A3;...
Oxidative phosphorylation -2.29 0.00e+0 93/133 (69.92%) COX8A;COX11;NDUFAB1;...
Ribosome -2.33 0.00e+0 113/158 (71.52%) RPL39;RPL27A;RPL37A;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 0.04uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.04uM - 10uM 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 0.12uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H