Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMFHAJS)

• Drug Name: Allantoin Drug Info
• Synonyms: allantoin; 97-59-6; 5-Ureidohydantoin; Glyoxyldiureide; 1-(2,5-dioxoimidazolidin-4-yl)urea; Glyoxyldiureid; Cordianine; Allantol; Sebical; Alantan; AVC/Dienestrolcream; Urea, (2,5-dioxo-4-imidazolidinyl)-; Hydantoin, 5-ureido-; Cutemol emollient; Uniderm A; Glyoxylic diureide; Glyoxylic(acid) diureide; (2,5-Dioxo-4-imidazolidinyl)urea; Psoralon; Septalan; Caswell No. 024; (2,5-dioxoimidazolidin-4-yl)urea; 5-Ureido-2,4-imidazolidindion; NSC 7606; Ureidohydantoin; CCRIS 1958; Allantoin [USAN:BAN]; Fancol TOIN; 5-Ureidohydrantoin
• Cross-matching ID:
  PubChem CID: 204
  ChEBI ID: CHEMBL15676
  CAS Number: CAS 97-59-6
  TTD Drug ID: D01HNL

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Glycosphingolipid biosynthesis	-1.80	2.47e-2	37/57 (64.91%)	ST8SIA1;HEXA;ST3GAL2;...
Thyroid hormone synthesis	-1.80	2.90e-2	66/75 (88%)	ATF6B;ASGR1;TTF1;...
Arachidonic acid metabolism	-1.83	3.39e-2	48/61 (78.69%)	PLA2G4A;CBR3;PLA2G3;...
Protein export	-1.90	1.45e-2	17/23 (73.91%)	SPCS3;SEC61A2;SRP14;...
Linoleic acid metabolism	-2.03	0.00e+0	21/29 (72.41%)	PLA2G4A;PLA2G3;CYP1A2;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	10uM	6H, 24H	Hide ▲

Kidney

Normal (Transformed)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HEK293T	CVCL_0063	Homo sapiens	0.125uM - 10uM	6H, 24H	Hide ▲

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	10uM	24H	Show ▼

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	0.125uM - 10uM	6H, 24H	Show ▼