Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMFIC0M)

Drug Name
Cinalukast Drug Info
Synonyms
Cinalukast [USAN:INN]; Ro 24-5913; Cinalukast (USAN/INN); Ro-24-5913; (E)-4-[[3-(2-(4-Cyclobutyl-2-thiazolyl)ethenyl)phenyl]amino]-2,2-diethyl-4-oxobutanoic acid; 3'-((E)-2-(4-Cyclobutyl-2-thiazolyl)vinyl)-2,2-diethylsuccinanilic acid; 4-({3-[(E)-2-(4-cyclobutyl-1,3-thiazol-2-yl)ethenyl]phenyl}amino)-2,2-diethyl-4-oxobutanoic acid; 4-[3-[(E)-2-(4-cyclobutyl-1,3-thiazol-2-yl)ethenyl]anilino]-2,2-diethyl-4-oxobutanoic acid
Therapeutic ClassAntiarrhythmic Agents
Cross-matching ID
PubChem CID
6436135
ChEBI ID
CHEMBL126598
CAS Number
CAS 128312-51-6
TTD Drug ID
D06PEB

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Chemokine signaling pathway 2.11 0.00e+0 163/192 (84.9%) RAC2;CCL2;CCL5;...
Viral protein interaction with cytokine and cytokine re... 2.03 0.00e+0 84/100 (84%) CCL2;CCL5;IL6;...
AGE-RAGE signaling pathway in diabetic complications 1.97 0.00e+0 97/100 (97%) CDKN1B;TGFBR2;CCL2;...
Complement and coagulation cascades 1.79 4.95e-2 76/85 (89.41%) PLAT;A2M;PLAU;...
Rheumatoid arthritis 1.78 4.13e-2 78/93 (83.87%) TLR4;CCL2;ICAM1;...
Mineral absorption 1.78 3.54e-2 48/60 (80%) MT1G;MT1F;MT1H;...
HIF-1 signaling pathway 1.78 3.09e-2 105/109 (96.33%) TLR4;CDKN1B;IL6;...
Focal adhesion 1.70 4.99e-2 180/201 (89.55%) RAC2;COL4A2;HGF;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H