Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMFIDA0)

Drug Name
BD-1047 Drug Info
Synonyms BD1047; BD 1047
Cross-matching ID
PubChem CID
188914
ChEBI ID
CHEMBL143360
CAS Number
CAS 138356-20-4
TTD Drug ID
D09CGH

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Nicotinate and nicotinamide metabolism -1.66 4.99e-2 25/35 (71.43%) SIRT5;NT5C2;NMRK2;...
Protein processing in endoplasmic reticulum -1.67 4.91e-2 127/171 (74.27%) SEC23B;CRYAB;EIF2S1;...
Antigen processing and presentation -1.71 3.90e-2 60/78 (76.92%) LGMN;HSP90AA1;HLA-E;...
Other glycan degradation -1.73 3.70e-2 13/18 (72.22%) MAN2B2;HEXA;AGA;...
Graft-versus-host disease -1.74 3.84e-2 32/42 (76.19%) GZMB;HLA-DQA1;IL2;...
Legionellosis -1.74 4.31e-2 51/57 (89.47%) HSPD1;VCP;CASP9;...
Rheumatoid arthritis -1.76 3.97e-2 78/93 (83.87%) TLR4;CTLA4;TEK;...
Steroid biosynthesis -1.76 4.35e-2 19/20 (95%) FDFT1;MSMO1;CYP51A1;...
Amino sugar and nucleotide sugar metabolism -1.81 3.54e-2 38/48 (79.17%) CYB5R3;CYB5R4;HEXB;...
Oxidative phosphorylation -1.82 4.42e-2 93/133 (69.92%) NDUFS4;ATP6V0E1;ATP5F1B;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H