Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMFIFTM)

Drug Name
BMS-707035 Drug Info
Synonyms HIV integrase inhibitors (HIV infection), BMS
Cross-matching ID
PubChem CID
54682040
CAS Number
CAS 729607-74-3
TTD Drug ID
D0Q9IE

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
DNA replication 1.90 2.34e-2 34/36 (94.44%) MCM4;POLE2;MCM2;...
Fanconi anemia pathway 1.80 4.39e-2 36/54 (66.67%) FANCL;FANCI;REV3L;...
One carbon pool by folate 1.80 2.93e-2 15/20 (75%) TYMS;MTR;MTHFD1;...
Kaposi sarcoma-associated herpesvirus infection -1.71 1.57e-2 172/193 (89.12%) TP53;GSK3B;NRAS;...
Viral myocarditis -1.73 1.54e-2 53/60 (88.33%) RAC1;HLA-DOA;CD40;...
Salmonella infection -1.73 1.55e-2 198/249 (79.52%) CASP1;KIF5B;ARF1;...
Measles -1.74 1.40e-2 133/139 (95.68%) IRAK4;TRADD;TLR4;...
AGE-RAGE signaling pathway in diabetic complications -1.75 1.34e-2 97/100 (97%) NRAS;MAPK10;IL1A;...
Fructose and mannose metabolism -1.75 1.34e-2 30/33 (90.91%) GMDS;ENOSF1;AKR1B1;...
Graft-versus-host disease -1.76 1.40e-2 32/42 (76.19%) IL2;HLA-DPB1;KIR3DL1;...
Influenza A -1.77 1.15e-2 156/172 (90.7%) MYD88;IL1A;SLC25A4;...
Pancreatic cancer -1.79 1.02e-2 75/76 (98.68%) PLD2;RALA;PLD1;...
Huntington disease -1.79 1.06e-2 233/306 (76.14%) POLR2K;POLR2F;PSMB3;...
Lipid and atherosclerosis -1.79 1.05e-2 190/215 (88.37%) CASP1;CCL2;TLR2;...
Staphylococcus aureus infection -1.81 8.82e-3 72/95 (75.79%) ITGB2;IL10;MASP1;...
Galactose metabolism -1.81 9.31e-3 26/31 (83.87%) HK1;HKDC1;LCT;...
Th17 cell differentiation -1.82 9.03e-3 95/107 (88.79%) TYK2;IL21;IL23A;...
Mineral absorption -1.83 9.60e-3 48/60 (80%) ATP2B1;MT1H;MT1HL1;...
Asthma -1.83 9.31e-3 25/31 (80.65%) IL10;MS4A2;HLA-DPB1;...
Inflammatory bowel disease -1.83 9.97e-3 58/65 (89.23%) IL21;IL23A;IL2;...
Colorectal cancer -1.84 8.59e-3 84/86 (97.67%) RALA;TP53;GSK3B;...
C-type lectin receptor signaling pathway -1.84 9.31e-3 93/104 (89.42%) NRAS;MAPK10;CLEC7A;...
Prion disease -1.85 1.02e-2 209/273 (76.56%) CREB3L2;KIF5B;ATP5PF;...
Tuberculosis -1.86 1.12e-2 159/180 (88.33%) ITGAM;MAPK10;MYD88;...
PD-L1 expression and PD-1 checkpoint pathway in cancer -1.87 1.09e-2 79/89 (88.76%) PPP3R1;TLR4;STAT3;...
Rheumatoid arthritis -1.87 1.05e-2 78/93 (83.87%) ATP6V0A4;TNFRSF11A;IL23A;...
Th1 and Th2 cell differentiation -1.91 3.99e-3 80/92 (86.96%) MAPK10;IL5;TBX21;...
Toll-like receptor signaling pathway -1.91 4.65e-3 94/104 (90.38%) TLR8;IRAK4;TLR4;...
Non-alcoholic fatty liver disease -1.95 5.58e-3 126/155 (81.29%) NDUFB2;MAPK11;FASLG;...
T cell receptor signaling pathway -1.99 0.00e+0 93/104 (89.42%) MAPK11;NCK1;CTLA4;...
Osteoclast differentiation -1.99 0.00e+0 117/127 (92.13%) GRB2;MAPK10;SYK;...
IL-17 signaling pathway -2.03 0.00e+0 84/94 (89.36%) GSK3B;MAPK10;IL5;...
TNF signaling pathway -2.05 0.00e+0 103/112 (91.96%) TRADD;CX3CL1;CREB3L2;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.04uM - 10uM 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.01uM - 10uM 24H