Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMFIR0S)

Drug Name
LY-255283 Drug Info
Synonyms GTPL3351; MolPort-009-018-745; HMS3649C08; ZINC27644044; SR-01000946596; SR-01000946596-1
Cross-matching ID
PubChem CID
122023
ChEBI ID
CHEMBL15766
CAS Number
CAS 117690-79-6
TTD Drug ID
D0Y2IH

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Cell cycle 1.94 3.37e-2 110/124 (88.71%) CHEK1;PCNA;YWHAH;...
Proximal tubule bicarbonate reclamation 1.90 2.81e-2 21/23 (91.3%) CA2;ATP1B3;SLC4A4;...
Collecting duct acid secretion 1.82 4.86e-2 22/27 (81.48%) CA2;ATP6V1D;ATP6V1A;...
D-Glutamine and D-glutamate metabolism 1.80 4.49e-2 5/5 (100%) GLUD2;GLUD1;GLS
p53 signaling pathway 1.75 4.49e-2 63/73 (86.3%) CYCS;CHEK1;RRM2;...
Intestinal immune network for IgA production 1.74 3.93e-2 38/48 (79.17%) HLA-DQA1;IL6;CD40;...
Antigen processing and presentation 1.71 4.99e-2 60/78 (76.92%) HSPA8;HLA-DQA1;HSPA4;...
Oocyte meiosis 1.70 4.83e-2 90/129 (69.77%) YWHAH;CCNB2;ADCY7;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H