Details of the Drug Pharmacogenomic Perturbation Atlas

MyVax Drug Info

MyVax Personalized Immunotherapy; GTOP-99; Personalized recombinant protein vaccines (cancer); Recombinant Id immunotherapy, Genitope; Recombinant idiotype protein vaccines, Genitope; Xi-20H5; Xi-3C9; Non-Hodgkin lymphoma vaccine, Genitope; Personalized recombinant protein vaccines (cancer), Genitope; Vaccine (NHL), Genitope; B-cell non-Hodgkins lymphoma vaccine, Genitope

Cross-matching ID

PubChem CID

638034

TTD Drug ID

D0O2JT

General Information of Drug (ID: DMFIWUL)

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Complement and coagulation cascades	2.19	0.00e+0	76/85 (89.41%)	CFI;SERPING1;C1S;...
Metabolism of xenobiotics by cytochrome P450	2.17	0.00e+0	49/77 (63.64%)	ADH5;AKR1C1;GSTT1;...
Retinol metabolism	2.10	0.00e+0	41/68 (60.29%)	ALDH1A1;ADH5;ALDH1A3;...
Porphyrin and chlorophyll metabolism	2.03	0.00e+0	23/43 (53.49%)	HMOX1;CP;UGT2B28;...
Steroid hormone biosynthesis	1.95	1.77e-3	43/61 (70.49%)	AKR1C2;AKR1C1;HSD11B1;...
Systemic lupus erythematosus	1.90	2.95e-3	45/135 (33.33%)	C1S;C1R;C1QB;...
Linoleic acid metabolism	1.88	5.06e-3	21/29 (72.41%)	PLA2G2A;CYP3A4;PLA2G12A;...
Drug metabolism	1.88	6.64e-3	78/151 (51.66%)	ADH5;GSTT1;GSTA1;...
Pentose and glucuronate interconversions	1.86	8.86e-3	17/34 (50%)	AKR1B10;SORD;UGDH;...
PPAR signaling pathway	1.80	1.68e-2	66/74 (89.19%)	SCD;HMGCS1;ACSL3;...
Arachidonic acid metabolism	1.79	1.85e-2	48/61 (78.69%)	PLA2G2A;GPX2;PTGIS;...
Fatty acid degradation	1.74	2.58e-2	40/43 (93.02%)	ECI2;ADH5;ACSL3;...
Peroxisome	1.69	3.61e-2	72/82 (87.8%)	ECI2;ACSL3;PXMP2;...
Primary immunodeficiency	1.69	3.35e-2	33/38 (86.84%)	BLNK;BTK;LCK;...
Proteasome	1.68	3.60e-2	44/46 (95.65%)	PSMA4;PSMB6;PSMD12;...
alpha-Linolenic acid metabolism	1.65	4.10e-2	17/25 (68%)	PLA2G2A;PLA2G12A;PLA2G5;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	10uM	6H, 24H

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	10uM	6H

Fibroblast

Nasopharyngeal carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
FIBRNPC	CVCL_UK07	Homo sapiens	10uM	6H, 24H

Hematopoietic system

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
ASC	CVCL_U602	Homo sapiens	10uM	24H

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	10uM	6H

Normal (Transformed)

Liver

Hepatoblastoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Hep G2	CVCL_0027	Homo sapiens	10uM	6H

Hepatocellular carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HuH-7	CVCL_0336	Homo sapiens	10uM	72H

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	10uM	6H, 24H

Non-small cell lung carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HCC515	CVCL_5134	Homo sapiens	10uM	6H

Normal (Fibroblast)

Prostate

Prostate carcinoma

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	10uM	6H