Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMFJ3VC)

Drug Name
DY131 Drug Info
Synonyms DY-131; GSK9089
Cross-matching ID
PubChem CID
5497124
ChEBI ID
CHEMBL93087
CAS Number
CAS 95167-41-2
TTD Drug ID
D06JPQ

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
AMPK signaling pathway -1.70 3.15e-2 106/120 (88.33%) CAMKK2;LEP;PPP2R3B;...
Systemic lupus erythematosus -1.71 3.50e-2 45/135 (33.33%) C1R;C2;C1S;...
Tryptophan metabolism -1.75 2.79e-2 35/42 (83.33%) TDO2;ACAT1;CAT;...
Terpenoid backbone biosynthesis -1.81 1.87e-2 18/22 (81.82%) HMGCS2;MVD;FDPS;...
Mitophagy -1.86 1.41e-2 56/68 (82.35%) BECN1;RELA;BNIP3;...
PPAR signaling pathway -1.91 4.61e-3 66/74 (89.19%) PDPK1;CD36;ACSBG1;...
Retinol metabolism -1.91 3.84e-3 41/68 (60.29%) RDH11;BCO1;CYP26B1;...
Malaria -1.97 2.56e-3 44/50 (88%) SDC2;GYPC;IL10;...
Glyoxylate and dicarboxylate metabolism -1.98 3.84e-3 23/30 (76.67%) AGXT;ACAT1;CAT;...
Steroid biosynthesis -2.21 0.00e+0 19/20 (95%) CYP27B1;FDFT1;EBP;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H